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Daniel Kramer¹, Robert Hilton¹, Jesse Roman¹

¹Division of Pulmonary, Allergy and Critical Care, Department of Medicine; Jane & Leonard Korman Respiratory Institute, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

The American journal of the medical sciences

|July 22, 2023

概括

COVID-19 感染可能导致肺纤维化,这是一个肺部痕状况. 建议接种疫苗,以减少感染的严重程度,并预防这种严重的呼吸道并发症.

科学领域:

肺部医学肺部医学
传染性疾病传染性疾病
病理学病理学病理学

背景情况:

由SARS-CoV-2引起的COVID-19大流行病导致全球数百万人死亡.
严重的SARS-CoV-2感染可以在肺部引发激烈的炎症反应,可能导致呼吸衰竭.
值得关注的是,COVID-19与肺纤维化之间的联系,其特点是过度的原体沉积和肺组织损伤.

研究的目的:

阐明SARS-CoV-2感染导致肺纤维化的机制.
了解病毒如何与 ангиотензин转化酶 (ACE) 受体结合,从而启动纤维化过程.
突出COVID-19后长期呼吸道并发症的可能性.

主要方法:

审查目前对肺部SARS-CoV-2病变发生的理解.
分析ACE受体结合在病毒诱导的炎症和氧化应激中的作用.
检查导致纤维细胞激活和细胞外基质沉积的信号通路.

主要成果:

SARS-CoV-2 感染通过ACE受体结合刺激氧化应激和炎症.
该病毒促进亲纤维细胞因子,导致纤维细胞的积累和激活.
这一过程导致了过度的细胞外基质沉积,损害了肺架构和气交换单元.

结论:

与COVID-19相关的肺纤维化甚至可以在病毒清除后发展,并可能导致不可逆转的肺损伤.
由于肺功能丧失,呼吸短促和运动不耐受等症状可能会持续存在.
预防措施,包括接种疫苗,对于减轻严重的COVID-19和随后的肺纤维化风险至关重要.

关键词:

恶化的加剧.纤维细胞细胞.间歇性肺病间歇性肺病这就是SARS-CoV-2病毒.疫苗疫苗疫苗疫苗

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