患有心力衰竭的患者中心上脂肪组织与左心室和心室功能之间的关联:系统性审查和元分析
Anhu Wu1, Zhuohao Yang1, Xinyu Zhang1
1National Key Laboratory for Innovation and Transformation of Luobing Theory, The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Current problems in cardiology
|July 22, 2023
概括
心脂肪组织 (EAT) 在心力衰竭中较高,具有保存的喷射分数 (HFpEF),但没有减少的喷射分数 (HFrEF). 在HFpEF与HFrEF中,EAT水平与心脏功能的相关性不同.
科学领域:
- 心脏病学 心脏病学
- 代谢研究研究 代谢研究
- 生物医学工程 生物医学工程
背景情况:
- 脊心脂肪组织 (EAT) 在心脏健康中发挥作用,在不同类型的心力衰竭中可能有不同的影响.
- 了解EAT和心力衰竭与减少喷射分数 (HFrEF) 和心力衰竭与保存喷射分数 (HFpEF) 之间的关联对于向治疗至关重要.
研究的目的:
- 系统地审查和元分析EAT与心力衰竭 (HF) 之间的关联.
- 评估EAT水平及其与HFrEF和HFpEF患者心脏功能的相关性.
主要方法:
- 从研究开始到2023年1月20日的研究的系统审查和元分析.
- 在高频与对照组中,EAT的计算标准平均差异 (SMD).
- 评估了EAT与左心房 (LA) /左心室 (LV) 功能参数之间的相关性.
主要成果:
- 与对照组相比,HFpEF患者的EAT显著更高 (SMD:0.61).
- 在总HF或HFrEF患者中,EAT并没有显著增加.
- 在HFrEF中,EAT与LVEF,LVEDVI,LAGLS正相关,与NT-ProBNP负相关.
- 在HFpEF中,EAT与LVMI,LVEDVI,LVESVI,LAVI,心脏素T,ECV正相关,与LVGLS,LAGLS负相关.
结论:
- EAT在HFpEF上升,但不是HFrEF.
- 在HFrEF中,较少的EAT与较差的LA功能有关,但不是LV功能.
- 在HFpEF中,增加的EAT与LA和LV功能受损有关.
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