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黑量子点通过增加脂质过氧化和铁积累,诱导肺细胞中的铁

Liangding Dou¹, Rong Liu¹, Zhaojizhe Wang²

¹State Key Laboratory of Vaccines for Infectious Diseases, Xiang an Biomedicine Laboratory, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Innovation Platform for Industry-Education Integration in Vaccine Research, School of Public Health, Xiamen University, Xiamen, 361102, Fujian, China.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

|July 22, 2023

概括

黑量子点 (BP-QDs) 暴露会通过诱导铁,一种依赖铁的细胞死亡,引起呼吸道毒性. 这项研究证实,BP-QD增加了脂质过氧化和铁在肺细胞和组织中的积累.

科学领域:

生物医学科学生物医学科学
毒理学毒理学毒理学
纳米技术纳米技术

背景情况:

黑量子点 (BP-QDs) 在生物医学方面显示出有前途.
通过在生产过程中吸入BP-QD的职业暴露可能导致呼吸道毒性.
氧化,依赖铁的细胞死亡的一种形式铁亡是这种毒性的潜在机制.

研究的目的:

为了调查BP-QDs的呼吸系统毒性.
阐明BP-QDs诱导的肺损伤的机制,重点关注铁亡.
在体外和体外模型中验证发现.

主要方法:

暴露人类支气管上皮细胞 (Beas-2B) 不同剂量的BP-QDs.
不侵入性气管灌注BP-QDs在小鼠中的不同剂量.
肺组织的病理检查和分子分析.
评估脂质过氧化,铁过载和谷氨水平.
分析铁灭症相关的蛋白质和mRNA表达.

主要成果:

暴露于BP-QD导致细胞内脂质过氧化和Beas-2B细胞中的铁过载.
暴露于BP-QDs的小鼠表现出铁过载,谷氨耗尽和肺组织中的脂质过氧化.
有证据表明,BP-QDs通过增加细胞内自由铁和多不和脂肪酸合成来诱导铁亡.
主要细胞似乎比癌细胞更敏感于BP-QDs诱导的损伤.

结论:

BP-QDs通过铁死诱导呼吸系统毒性.
该机制涉及增加的脂质过氧化和铁积累.
这些发现强调了了解在职业环境中纳米粒子毒性的重要性.

关键词:

豆类-2B 种子黑量子点是指黑的量子点.铁化是铁化的一种.肺部有毒性肺部有毒性

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