在Plasmodium物种中异常分歧的乌比基因和蛋白质
Thomas Dalhuisen1,2, Lindsey J Plenderleith1,2, Ismail Ursani1,2
1Institute of Ecology and Evolution, University of Edinburgh, Edinburgh, United Kingdom.
Genome biology and evolution
|July 22, 2023
概括
这项研究揭示了疟疾寄生虫中泛素基因的新奇进化路径. 杆菌寄生虫最近在泛素序列中呈现出快速分歧,这挑战了以前对基因进化的理解.
科学领域:
- 进化生物学是进化的生物学.
- 分子遗传学 分子遗传学
- 寄生虫学的寄生虫学
背景情况:
- 乌比基是一种高度保存的蛋白质,在细胞过程中起着至关重要的作用.
- 虫寄生虫中的乌比基因,包括RPS27a和RPL40融合和多虫基因,正在研究它们的进化动态.
- 以前的研究表明,原生体中由RPS27a融合基因编码的乌比奎丁存在分歧.
研究的目的:
- 为了研究哺乳动物疟疾寄生虫 (Plasmodium物种) 中的无处不在基因的进化轨迹.
- 为了识别和描述Plasmodium中分离的泛素序列的新型形式.
- 探索Plasmodium ubiquitin基因中的进化机制 (协同进化与出生和死亡).
主要方法:
- 在不同类型的Plasmodium中对ubiquitin基因序列进行比较基因组分析.
- 遗传学分析,以追踪乌比奎丁基因变异的进化历史.
- 在无处不在的基因中识别特定的序列改变,例如编码子插入.
主要成果:
- 由RPS27a融合基因编码的乌比基因在Plasmodium中显示出显著的分歧,与其他原生动物的发现一致.
- 两种以前罕见的分离的泛素序列形式最近在Plasmodium亚属分离期间出现.
- 由RPL40融合基因编码的泛素在两个不同的基因系中经历了两次快速分歧.
- 在一个Plasmodium血统的多基因中观察到一个单一的编码子插入,以前是Rhizaria独有的.
- 原菌的基因显示出协同进化的明确证据,包括在多基因内观察到的密码子插入的广泛传播.
结论:
- 在Plasmodium中,无处不在的基因的演变比以前被认为的更为动态,最近出现了快速分歧事件.
- 杆菌寄生虫独立地获得并传播了独特的泛素序列特征,例如RPL40基因分歧和代码子插入.
- 这些发现支持协同进化作为Plasmodium中泛素基因进化的驱动力,特别是对于聚聚素基因.
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