在随机对照试验中的术后急性呼吸困扰综合征
Vassilis G Giannakoulis1, Eleni Papoutsi1, Vassileios Kaldis2
1First Department of Critical Care Medicine and Pulmonary Services, Evangelismos Hospital, National and Kapodistrian University of Athens Medical School, Greece.
在临床试验中,术后急性呼吸困扰综合征 (ARDS) 的代表性下降,但在2011年之后显示出稳定的趋势. 手术后ARDS患者的死亡率较低,年龄和液体平衡预测了结果.
科学领域:
- 关键护理医学 关键护理医学
- 肺部病理学 肺部病理学
- 手术并发症 手术并发症
背景情况:
- 急性呼吸窘迫综合征 (ARDS) 是手术后的一种严重并发症.
- 在临床试验中了解术后ARDS的趋势和特征对于患者的治疗结果至关重要.
研究的目的:
- 在临床试验中分析术后ARDS患者代表性的时间趋势.
- 确定术后ARDS的明显临床特征和死亡预测因素.
主要方法:
- 来自ARDS网络和CTN-PREVENT的7项随机对照试验的二次分析.
- 将ARDS患者分为术后和非术后组.
主要成果:
- 手术后的ARDS占ARDS患者的4.8%;从2000年至2011年,试验代表性下降,然后稳定.
- 手术后的ARDS有较低的90天死亡率 (24.6%) 与非手术后的ARDS (30.9%).
- 年龄,免疫抑制和积极的液体平衡预测了术后ARDS的90天死亡率.
结论:
- 术后ARDS试验代表性已经下降并稳定.
- 术后的ARDS与非术后的ARDS相比,与更好的预后有关.
- 阳性液体平衡是术后ARDS中死亡率的一个关键预测因素.
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