相关实验视频

Updated: Jul 22, 2025

An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes

An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes

Published on: April 26, 2019

胰岛素受体基质2基因Gly1057Asp多态性是非酒精性脂肪肝疾病的危险因素

Shadi Nouri¹, Touraj Mahmoudi², Farzaneh Hojjati²

¹Department of Radiology, School of Medicine, Arak University of Medical Sciences, Arak, Iran.

Laboratory medicine

|July 22, 2023

概括

胰岛素受体基质2 (IRS2) Gly1057Asp Asp/Asp基因型与患非酒精性脂肪肝疾病 (NAFLD) 的风险更高有关. 需要进一步的研究来证实这种关系在不同的人群中.

科学领域:

遗传学是一个遗传学.
肝病学肝病学是一种肝病学.
代谢疾病代谢疾病

背景情况:

非酒精性脂肪肝 (NAFLD) 是一个日益严重的全球健康问题.
NAFLD与胰岛素耐药性密切相关.
胰岛素受体基质2 (IRS2) 基因在胰岛素信号通路中发挥作用.

研究的目的:

研究IRS2基因的Gly1057Asp多态 (rs1805097) 与NAFLD之间的关联.
为了确定特定的IRS2基因型是否影响NAFLD易感性.

主要方法:

病例控制研究涉及135名经活检证明的NAFLD患者和135名对照人群.
聚合酶连锁反应-限制片段长度多态性被用于IRS2的基因定型.
分析包括基因型和等位基因分布,符合哈迪-韦恩伯格平衡.

主要成果:

IRS2 Gly1057Asp多态的Asp/Asp基因型与NAFLD有显著的关联.
与Gly/Gly基因型相比,具有Asp/Asp基因型的个体患NAFLD的风险增加了2.1倍 (OR=2.10,95%CI=1.23-3.97).
在这两组中都没有观察到与哈迪-韦恩伯格平衡的显著偏差.

结论:

IRS2 Gly1057Asp多态的Asp/Asp基因型被确定为增加NAFLD易感性的潜在标志物.
这些发现代表了第一个证据,将这种特定的IRS2基因型与NAFLD风险联系起来.
建议在不同族群中进行进一步的验证研究,以证实这些结果.

关键词:

在Gly1057Asp中使用.美国国税局2 IRS2 这是NAFLD.胰岛素受体基质 2 胰岛素受体基质多形态主义的多态主义.价格为1805097 美元.

更多相关视频

Optimized Analysis of In Vivo and In Vitro Hepatic Steatosis

Optimized Analysis of In Vivo and In Vitro Hepatic Steatosis

Published on: March 11, 2017

Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing ChIP-seq

Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing ChIP-seq

Published on: April 19, 2013

相关概念视频

Insulin: The Receptor and Signaling Pathways

Insulin: The Receptor and Signaling Pathways

Insulin action is mediated through a receptor tyrosine kinase, akin to the IGF-1 receptor. The number of receptors per cell varies significantly, from 40 on erythrocytes to 300,000 on adipocytes and hepatocytes. The insulin receptor consists of linked α/β subunit dimers, forming a heterotetramer glycoprotein with two extracellular α subunits and two β subunits spanning the membrane. The α subunits inhibit the inherent tyrosine kinase activity of the β subunits, but...

Diabetes Mellitus: Type 2 and Gestational

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...

Diabetes Mellitus: Overview and Type I Subtype

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...