在NHANES 2009-2010年肥胖人口中,C-反应蛋白和牙周炎之间的关联
Jiangling Sun1,2, Wang Wang3, Dongdong Li4
1Department of Science and Education, Guiyang Stomatological Hospital, 550002, Guizhou, China.
BMC oral health
|July 22, 2023
概括
身体质量指数 (BMI) 显示没有与牙周炎的联系. 然而,C反应性蛋白 (CRP) 水平与肥胖个体的牙周炎有显著的相关性,这表明在这个群体中炎症和牙疾病之间存在联系.
科学领域:
- 牙周病学 牙周病学
- 公共卫生 公共卫生
- 生物标志物 生物标志物
背景情况:
- 现有研究表明,身体质量指数 (BMI),C反应蛋白 (CRP) 和牙周炎之间存在关联.
- 国家健康和营养检查调查 (NHANES) 数据库为调查这些关联提供了宝贵的资源.
研究的目的:
- 调查CRP和BMI与牙周炎的关联.
- 利用NHANES数据库中的数据进行全面分析.
主要方法:
- 从2009-2010年NHANES周期中对3602名参与者的横截面分析.
- 使用Eke的标准定义牙周炎,将参与者分为四组.
- 通过描述性统计,多变量回归和子组分析测试统计学意义,并对混因素进行调整.
主要成果:
- 没有与牙周炎发展相关的BMI的统计学上显著差异.
- 在调整多个混因素后,CRP在肥胖子组中与牙周炎有显著的相关性 (OR 1.2,95% CI 1.0-1.5).
- 根据年龄,性别,种族,社会经济因素,生活方式选择和并发症进行调整的混因子.
结论:
- 在美国人口中,CRP水平和牙周炎患病率之间存在关联.
- 这种关联在肥胖人口中特别观察到.
- 需要进一步的研究来阐明潜在的机制,并验证这些发现.
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