在韩国对帕金森病和癌症之间的逆关系进行了纵向研究
So Young Kim1, Hyo Geun Choi2,3, Yoo Hwan Kim4
1Department of Otorhinolaryngology-Head & Neck Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
NPJ Parkinson's disease
|July 22, 2023
概括
帕金森病 (PD) 与韩国成年人的整体癌症风险和大多数特定癌症类型相反相关. 需要进一步的研究来了解这种观察到的反向关系的潜在机制.
科学领域:
- 流行病学 流行病学
- 在瘤学瘤学.
- 神经学 神经学
背景情况:
- 帕金森病 (PD) 和癌症之间的联系仍然不清楚,亚洲人群的研究有限.
- 调查这种关联对于了解疾病途径和潜在的共同风险因素至关重要.
研究的目的:
- 检查帕金森病 (PD) 与随后发展各种癌症的风险之间的关联.
- 分析来自40岁及以上的韩国成年人代表样本的纵向数据.
主要方法:
- 使用韩国国家医疗保险数据库索赔数据 (2002-2019) 进行的回顾性队列研究.
- 确定了8,381名PD患者和33,524名没有PD的匹配对照.
- 使用多变量考克斯比例危险回归分析来估计相关性.
主要成果:
- 患有PD的患者的整体癌症风险显著降低 (aHR=0.63).
- 在胃,甲状腺,结直肠,肺,肝,胰腺癌和血液恶性瘤中观察到不良关联.
- 对于膀,胆囊和胆道,或癌,没有发现显著的关联.
结论:
- 帕金森病 (PD) 与患上大多数常见癌症类型的风险降低有关.
- 观察到的反向关联需要进一步研究它们的潜在病原遗传机制.
更多相关视频
06:07Author Spotlight: Establishing a New Fluorescence-Based Protocol for In Vivo Mitochondrial Morphology Analysis in Parkinson's Disease
Published on: June 23, 2023
1.6K
07:26Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking
Published on: September 26, 2019
7.9K
相关概念视频
Parkinson's Disease: Overview
601
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
601
Longitudinal Research
12.0K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
12.0K
Cancer Survival Analysis
390
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
390
Parkinson's Disease: Treatment
301
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
301
Cancer
48.8K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
48.8K
Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K
