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延长寿命的干预措施诱导了老鼠肝脏中脂肪酸氧化的一致模式

Kengo Watanabe¹, Tomasz Wilmanski¹, Priyanka Baloni²

¹Institute for Systems Biology, Seattle, WA, USA.

Communications biology

|July 22, 2023

概括

多次延长寿命的干预措施加强了生物调节,特别是在脂肪酸氧化和免疫反应方面. 系统层面的分析显示,在各种治疗中,与长寿相关的分子变化得到了保留.

科学领域:

老年学和系统生物学系统生物学
分子生物学和衰老研究分子生物学和衰老研究

背景情况:

衰老的特点是恒温的下降和分子调节失调.
了解衰老需要对生物过程进行系统级的研究.

研究的目的:

在延长寿命的干预措施下调查系统分子调节的变化.
在不同的长寿干预中识别保存和独特的监管模式.

主要方法:

对小鼠肝脏蛋白质组学和转录组学数据的差异等级保护 (DIRAC) 分析.
转录组学数据与小鼠基因组规模代谢模型的整合.

主要成果:

机械上不同的干预措施 (阿卡尔,17α-雌激醇,拉巴胺素,卡路里限制) 通常会收紧生物模块的调节.
在脂肪酸氧化,免疫反应和应激反应模块中观察到的保持紧缩模式.
蛋白质和转录DIRAC模式之间的不一致性表明,盖帽独立翻译的作用.

结论:

系统层面的方法有效地识别了老化和寿命中的保存的分子过程.
延长寿命的干预措施趋于收紧监管网络,特别是在新陈代谢和免疫通路中.
增强的上限独立翻译可能有助于保持监管收紧.

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