持续的正气道压力 (CPAP) 对于早产性呼吸暂停
Jacqueline J Ho1, Irena Zakarija-Grkovic2, Jia Wen Lok3
1Department of Paediatrics, RCSI & UCD Malaysia Campus (formerly Penang Medical College), George Town, Malaysia.
The Cochrane database of systematic reviews
|July 23, 2023
概括
有限的研究表明,持续正气道压力 (CPAP) 可能不比其他治疗早产儿呼吸暂停 (AoP) 的方法更有效. 需要更多的研究来确定最佳的CPAP使用和有效性.
科学领域:
- 新生儿医学 新生儿医学
- 呼吸系统生理学 呼吸系统生理学
- 临床试验 临床试验
背景情况:
- 过早性呼吸暂停 (AoP) 是早产婴儿常见的呼吸问题,可能与神经发育迟缓有关.
- 持续正气道压力 (CPAP) 用于呼吸困难,但其对AoP的疗效尚不清楚.
研究的目的:
- 评估CPAP对早产婴儿AoP的影响.
- 为了比较AoP治疗的不同CPAP输送系统.
主要方法:
- 随机和准随机对照试验的系统审查.
- 在主要数据库 (科克兰图书馆,MEDLINE,Embase,CINAHL) 进行搜索,截至2022年9月.
- 使用GRADE方法来评估结果的证据确定性,例如CPAP失败和呼吸暂停的频率.
主要成果:
- 包括4项涉及138名早产婴儿的试验;没有研究将CPAP与支持性护理或机械通风进行比较.
- 关于AoP的可变流量CPAP,呼吸机CPAP和泡CPAP之间的差异,证据非常不确定.
- 神经发育结果和不良事件在各个研究中都没有一致报告.
结论:
- 目前的证据不足以确定任何CPAP设备在早产婴儿治疗AoP的优越性.
- 偏见的高风险和单个研究比较的有限数据需要进一步的研究.
- 需要进行额外的试验,以澄清CPAP在管理AoP中的作用和最佳使用.
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