功能分级的多孔体间的生物机械分析,用于腰椎脊柱融合
Rahul Gautam Talukdar1, Ceby Mullakkara Saviour2, Santanu Dhara3
1Advanced Technology Development Centre, Indian Institute of Technology Kharagpur, Kharagpur, 721 302, West Bengal, India.
Computers in biology and medicine
|July 23, 2023
概括
功能分级多孔 (FGP) 机体间为传统设计提供了一个有前途的替代方案. 这些新的子显示出减少的微运动和有利的骨密度变化,平衡了脊髓融合的机械特性和毛孔性.
科学领域:
- 生物材料工程 生物材料工程
- 整形外科手术 整形外科手术
- 计算力学 计算力学 计算力学
背景情况:
- 间体对于脊髓融合至关重要,但优化它们的机械性能和多孔性仍然是一个挑战.
- 功能分级多孔材料 (FGP) 通过改变多孔度来平衡硬度和骨整合提供了一个潜在的解决方案.
- 了解FGP周围的负载转移和骨重塑对于预测临床结果至关重要.
研究的目的:
- 用有限元素分析研究FGP体间周围的机械行为和骨密度变化.
- 为了比较FGP子的有效性与不同的孔径水平对固体和均多孔的子.
- 评估植入物 - 骨接口条件对子性能和骨位置的影响.
主要方法:
- 完整的和植入的腰椎功能脊柱单元 (FSU) 的有限元模型的开发.
- 模拟各种多孔度 (48%,65%,78%) 和接口条件 (结合与解结合) 的FGP子周围的负载转移和应变分布.
- 与固体和均多孔 (78%) 的子相比,FGP子的比较.
主要成果:
- 与固体类子相比,FGP子在周围假肢骨中表现出较少的峰值应变.
- 一个结合的植入物-骨接口促进了较高的骨位 (11-20%) 比一个不结合的接口 (6-10%).
- 与固体类子 (116微米) 相比,FGP子的平均微运动 (70-106微米) 减少了.
结论:
- 在脊柱融合中,FGP体间是一种可行的替代固体和均多孔的替代方案.
- 渐变的多孔性设计有效平衡机械强度和多孔性,可能增强骨整合和减少应力屏蔽.
- 优化植入物-骨接口条件对于最大限度地发挥FGP子技术的好处至关重要.
相关概念视频
Classification of Bones
The bones of the human skeletal system are of varied shapes, sizes, and functions. They can be classified based on their shape and function into four major classes: long bones, short bones, flat bones, and irregular bones. Some classifications include a fifth type, the sesamoid bones, as a separate class, whereas others categorize them under short bones.
Long and Short Bones
The appendicular skeleton, particularly the upper and lower limbs, is primarily made of long and short bones. The long...
Long and Short Bones
The appendicular skeleton, particularly the upper and lower limbs, is primarily made of long and short bones. The long...
Gross Anatomy of Bone
The two main features of a long bone are the diaphysis and the epiphysis.
The diaphysis is the tubular shaft that runs between the proximal and distal ends of the bone. The walls of the diaphysis are composed of dense and hard compact bone made of numerous osteons — the functional unit of the compact bone. The hollow region in the diaphysis is called the medullary cavity, which harbors the bone marrow. In infants and children, this marrow cavity is filled with red marrow, whereas in adults, it...
The diaphysis is the tubular shaft that runs between the proximal and distal ends of the bone. The walls of the diaphysis are composed of dense and hard compact bone made of numerous osteons — the functional unit of the compact bone. The hollow region in the diaphysis is called the medullary cavity, which harbors the bone marrow. In infants and children, this marrow cavity is filled with red marrow, whereas in adults, it...
General Structure of a Vertebra
A typical vertebra, with the exception of the sacrum and coccyx, consists of a body, a vertebral arch, and seven different projections termed processes. The anterior portion of the vertebrae, the body, supports about half the body’s weight. The vertebral bodies progressively increase in size and thickness from the cervical region to the lumbar region of the vertebral column. The intervertebral discs present between the bodies of adjacent vertebrae firmly unites them, forming a continuous column.
Functional Classification of Joints
Functional Classification of Joints
The functional classification of joints is determined by the amount of mobility between the adjacent bones. Joints are functionally classified as a synarthrosis or immobile joint, an amphiarthrosis or slightly moveable joint, or as a diarthrosis, a freely moveable joint. Fibrous and cartilaginous joints can be functionally classified as either synarthroses or amphiarthroses, whereas all synovial joints are classified as diarthroses.
Synarthrosis
An immobile...
The functional classification of joints is determined by the amount of mobility between the adjacent bones. Joints are functionally classified as a synarthrosis or immobile joint, an amphiarthrosis or slightly moveable joint, or as a diarthrosis, a freely moveable joint. Fibrous and cartilaginous joints can be functionally classified as either synarthroses or amphiarthroses, whereas all synovial joints are classified as diarthroses.
Synarthrosis
An immobile...
Structural Classification of Joints
Joints, also known as articulations, are classified based on their structural characteristics, i.e., based on whether the articulating surfaces of the adjacent bones are directly connected by fibrous connective tissue or cartilage, or whether the articulating surfaces contact each other within a fluid-filled joint cavity. These differences serve to divide the joints of the body into three structural classifications.
A fibrous joint is where the adjacent bones are united by fibrous connective...
A fibrous joint is where the adjacent bones are united by fibrous connective...


