透析治疗中的内分泌干扰剂:文献综述
Guillaume Cambien1, Antoine Dupuis1, Jérémy Guihenneuc1
1Université de Poitiers, CNRS, EBI, F-86000, Poitiers, France; Université de Poitiers, CHU de Poitiers, INSERM, Centre d'investigation clinique CIC1402, Axe Santé environnementale, Poitiers, France; Biology-Pharmacy-Public Health Department, University Hospital of Poitiers, 2 Rue de La Miletrie, 86021 Poitiers CEDEX, France; Faculty of Medicine and Pharmacy, University of Poitiers, TSA 51115, 86073 Poitiers Cedex, France.
Environment international
|July 23, 2023
概括
被透析的末期病患者 (ESKDD) 面临由于医疗器械的排泄和泄漏受损而过度暴露于内分泌干扰化学物质 (EDC). 新的欧盟法规旨在减少这种风险.
科学领域:
- 毒理学 毒理学 毒理学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 环境健康 环境健康
背景情况:
- 内分泌干扰化学物质 (EDC) 干扰激素功能,造成不良健康影响.
- 在透析中患有末期脏疾病 (ESKDD) 的患者有EDCs的脏消除受损.
- 在透析中使用的医疗器械可能会浸出EDC,增加患者的暴露.
研究的目的:
- 在ESKDD患者中审查和总结EDC暴露.
- 确定导致该人群中EDC过度暴露的因素.
主要方法:
- 进行了全面的文献审查.
- 在PubMed,Embase和Web of Science数据库中进行了搜索.
- 分析中包括了26项相关研究.
主要成果:
- 发现的常见EDC包括双A (BPA),双S (BPS),双B (BPB),双Nonylphenol和双酸盐 (DEHP,DBP,BBP).
- 患有ESKDD的患者过度暴露于BPA,BPS,BPB和DEHP.
- 带有聚碳酸外和聚硫纤维的透析器有助于BPA过度暴露.
- 与血液透析相比,腹腔透析和血液过似乎可以减少EDC暴露.
- 在透析过程中,DEHP水平会增加,特别是含有这种可塑剂的PVC设备.
结论:
- 患有ESKDD的患者对各种EDC暴露过度.
- 透析方式和医疗器械成分是影响暴露水平的关键因素.
- 预计欧盟对医疗器械的新法规将减轻ESKDD患者的EDC暴露.
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