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在看似健康的中年成人中,基线功能和癌症风险
Yonatan Moshkovits1, Adam Goldman2, Pazit Beckerman3
1Leviev Heart Center, Sheba Medical Center, Ramat-Gan, Israel; Sackler School of Medicine, Tel Aviv University, Tel-Aviv, Israel.
Cancer epidemiology
|July 23, 2023
概括
轻度功能受损,以估计的膜过率 (eGFR) 定义为低于60毫升/分钟/1.73米2,与癌症风险增加有关,特别是前列腺癌. 建议在功能下降的个体进行早期查和干预.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 轻度功能下降与癌症风险之间的关系尚未得到充分证实.
- 这项研究调查了估计的淋巴细胞过率 (eGFR) 与明显健康的成年人癌症发病率之间的关联.
研究的目的:
- 探索不同水平的功能与患全部位和特定部位癌症的风险之间的关联.
- 为了确定与功能受损相关的特定癌症类型.
主要方法:
- 每年对25073名年龄在40-79岁之间的没有癌症的成年人进行了随访.
- 使用CKD-EPI方程计算估计的淋巴球透率 (eGFR),并将其分为四组:<60,60-74,75-89和≥90毫升/分钟/1.73米2.
- 癌症发病率数据来自国家登记处,并使用多变量Cox模型进行分析.
主要成果:
- 随着eGFR水平的降低 (eGFR <60:1.4倍以上的风险),观察到全部位癌症的风险更高.
- 在所有降低的eGFR类别中发现前列腺癌的风险明显增加.
- 低于60的EGFR与黑色素瘤风险增加2.0倍和妇科癌症风险增加3.7倍有关.
结论:
- 慢性病 (CKD) 阶段2或更严重的慢性病独立地与癌症发病率的风险增加有关.
- 前列腺癌的风险在功能受损的个体中尤其显著.
- 早期干预和有针对性的癌症查对于患有CKD第二阶段及以上的个体至关重要,以减轻癌症负担.
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