贝赫塞特的患者对COVID-19疫苗接种的反应
Bindi Gokani1, Sarah Sacoor1, Georgia R Leisegang2
1London Behçet's Centre, Royal London Hospital, Barts Health London, UK.
Clinical immunology (Orlando, Fla.)
|July 23, 2023
概括
接受免疫抑制剂的贝切特病患者对COVID-19疫苗的免疫反应较弱. 对于这个群体来说,mRNA疫苗更有效,更安全.
科学领域:
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
- 疫苗学 疫苗学 疫苗学
背景情况:
- SARS-CoV-2 感染可以引起类似于贝切特病 (BD) 的多系统炎症.
- 针对BD的免疫抑制疗法引起了人们对COVID-19疫苗在患者中的有效性和安全性的担忧.
- 鉴于潜在的疾病爆发和免疫力改变,评估BD患者的疫苗反应至关重要.
研究的目的:
- 评估与健康对照组相比,贝塞特病患者的COVID-19疫苗免疫反应.
- 调查影响疫苗反应的因素,包括年龄,性别,疾病活性,BD表型和免疫抑制药物.
- 评估COVID-19疫苗接种对BD患者免疫细胞,免疫球蛋白,血栓性和甲状腺功能的影响.
主要方法:
- 在BD患者和疫苗接种后的健康对照中测量抗尖峰IgG水平的比较研究.
- 免疫参数的分析:T和B细胞,免疫球蛋白,血栓友标志物和甲状腺功能.
- 基于年龄,性别,疾病活性,BD表型和药物治疗的BD患者反应的分层.
主要成果:
- 接受免疫抑制药物的贝切特病患者对COVID-19疫苗的免疫反应减弱.
- 40岁以上的个体和具有神经性BD表型的个体表现出较低的疫苗反应.
- 与传统疫苗相比,mRNA COVID-19 疫苗显示出更高的有效性和更好的副作用概况.
结论:
- 在贝塞特病患者的免疫抑制疗法显著影响COVID-19疫苗免疫性.
- 年龄和特定的BD表型 (神经学) 与疫苗有效性降低有关.
- 由于提高了疗效和耐受性,mRNA COVID-19 疫苗被推用于贝切特病患者.
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