在成功的以创伤为重点的PTSD治疗后,与创伤相关的刺激的P3a振幅降低
Gail D Tillman1, Elizabeth Ellen Morris1, Christina Bass1
1Callier Center, University of Texas at Dallas, Dallas, TX, USA.
Biological psychology
|July 23, 2023
概括
重复性跨磁刺激 (rTMS) 与认知处理疗法 (CPT) 结合,有效地减少了创伤后应激障碍 (PTSD) 的退伍军人中与创伤后应激障碍 (PTSD) 相关的神经反应,与PTSD症状的减少相关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
背景情况:
- 对创伤刺激的P3a振幅升高与创伤后应激障碍 (PTSD) 有关.
- 创伤后应激障碍治疗对这种神经反应的影响仍然不清楚.
- 了解这些变化对于完善治疗干预至关重要.
研究的目的:
- 为了研究P3a振幅和延迟在PTSD治疗后对创伤相关刺激的反应的变化.
- 为了确定是否积极的重复性横磁性刺激 (rTMS) 与假装的rTMS相比增强了治疗效果.
- 探索神经变化与战斗退伍军人的症状减轻之间的相关性.
主要方法:
- 一个随机对照试验的二次分析,涉及55名美国退伍军人与战斗相关的PTSD.
- 参与者接受了积极的或假的rTMS与认知处理疗法 (CPT+A) 结合.
- 使用与创伤相关的和无关的分心因子的三条件视觉奇怪任务来测量治疗前和治疗后6个月的P3a反应.
主要成果:
- 治疗后观察到P3a振幅和对创伤相关刺激的响应时间下降.
- 这种减少与PTSD症状严重程度的减少有显著的相关性.
- 与假rTMS + CPT组相比,活跃rTMS + CPT组的幅度变化更大.
结论:
- 与CPT相结合的RTMS可能会减少PTSD中的过度兴奋和威胁偏差.
- 这些神经变化表明rTMS在增强创伤集中治疗的有效性方面起着有益的作用.
- 这些发现支持使用rTMS作为PTSD的辅助治疗.
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