早期非小细胞肺癌的SABR:肺功能变化,呼吸不良和生活质量
Julie Ahn1, Roland Yeghiaian-Alvandi2, Fiona Hegi-Johnson3
1Sydney West Radiation Oncology Network (SWRON), Sydney, New South Wales, Australia.
概括
针对非小细胞肺癌 (NSCLC) 的立体除性放射治疗 (SABR) 在18个月后显示,强迫呼气体积在1秒内 (FEV1) 显著下降. 吸烟包年预测肺功能下降和呼吸障碍恶化.
科学领域:
- 肺部医学 肺部医学
- 在瘤学瘤学.
- 辐射疗法 辐射疗法
背景情况:
- 立体除性放射治疗 (SABR) 是一种治疗早期非小细胞肺癌 (NSCLC) 的方法.
- 评估SABR对肺功能和生活质量的长期影响至关重要.
研究的目的:
- 评估用SABR治疗的NSCLC患者的肺功能测试 (PFT) 和生活质量 (QoL) 结果.
- 确定PFT和QoL变化的预测因素.
主要方法:
- 一项前性队列研究 (SSBROC) 涉及119名用SABR.com治疗的NSCLC患者.
- 在基线和6个月间隔至18个月内收集了PFT和QoL (包括呼吸障碍) 测量结果.
- 协同变量分析 (ANCOVA) 用于确定18个月后结果的预测因素.
主要成果:
- 在SABR治疗后18个月 (−0.11 L) 观察到1秒内强迫呼气体积 (FEV1) 的统计学显著下降.
- 增加的吸烟包年预计将减少一氧化碳和FEV1.1的扩散能力.
- 患者报告的呼吸障碍得分在18个月后显著恶化,但没有早些时候. 没有发现呼吸障碍恶化的预测因素.
结论:
- 对NSCLC的SABR治疗导致FEV1在18个月后显著下降.
- 吸烟史是SABR后肺功能减弱的预测因素.
- 患者报告的呼吸障碍恶化表明潜在的疾病进展或并发症影响.
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