使用JADER和FAERS数据库对光学异构体esomeprazole和omeprazole的结构性表征
Mami Neishi1, Hirofumi Hamano2, Takahiro Niimura3
1Faculty of Pharmacy, Department of Pharmacy, Shujitsu University, 1-6-1 Nishikawara, Nakaku, Okayama 703-8516, Japan.
Toxicology and applied pharmacology
|July 23, 2023
概括
与抗血小板药物一起使用时,埃索梅普拉 (EPZ) 与奥梅普拉 (OPZ) 相比显示出潜在的更好的安全性,在大型数据库中检测到的不良事件信号较少.
科学领域:
- 药理学 药理学是指药理学的学科.
- 药品安全 药品安全
- 临床药房 临床药房
背景情况:
- 相比于赛血的赛血 (OPZ),与赛血 (EPZ) 的S-反体相比,埃索梅普拉 (EPZ) 的安全概况尚未完全理解.
- 研究质子抑制剂和常见的抗血小板和抗血栓药物之间的潜在药物相互作用至关重要.
研究的目的:
- 为了比较埃索梅普拉 (EPZ) 和欧梅普拉 (OPZ) 与西洛斯塔,克洛皮多格雷尔和普拉苏格雷尔同时使用时的安全性.
- 通过大规模的不良事件数据库,识别与这些药物组合相关的潜在不良事件信号.
主要方法:
- 使用了日本药物不良事件报告 (JADER) 和FDA不良事件报告系统 (FAERS) 数据库.
- 使用MedDRA术语提取出血,栓塞和血栓的不良事件数据.
- 使用95%置信区间计算报告的赔率比率和评估信号存在.
主要成果:
- 埃索梅普拉 (EPZ) 与西洛斯塔和克洛皮多格雷尔结合时,与奥梅普拉 (OPP) 相比,显示出较少的不良事件信号.
- 奥梅普拉 (OPP) 显示了用克洛皮多格雷尔的动脉栓塞和血栓的信号,以及用西洛斯塔的静脉/动脉栓塞和血栓.
- 在与普拉苏格雷尔联合使用时,对这两种药物都没有检测到任何显著的不良事件信号.
结论:
- 埃索梅普拉 (EPZ) 在特定药物组合中显示出可能比奥梅普拉 (OPP) 更有利的安全性.
- 这些发现支持埃索梅普拉 (EPZ) 具有降低对CYP代谢敏感性的设计特征.
- 大数据分析证实了对抑制剂的明显安全考虑.
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