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京颗粒 (Jingfang Granules) 通过调节PI3K/Akt/mTOR信号通路来缓解白素引起的急性肺损伤

Xingxu Sun¹, Haixin Xiang², Zhong Liu³

¹School of Traditional Chinese Medicine, Guangdong Pharmacuetical University, Guangzhou, 510006, China; State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, Lunan Pharmaceutical Group Co. Ltd., Linyi, 276005, China.

Journal of ethnopharmacology

|July 23, 2023

概括

京颗粒通过降低PI3K/Akt/mTOR通路的调节来保护免受白素引起的急性肺损伤. 这种传统中医的干预也调节了关键的代谢途径,提供了一种新的治疗方法.

科学领域:

药理学药理学是指药理学的学科.
传统中国医药传统中国医药
肺部医学肺部医学

背景情况:

急性肺损伤 (ALI) 是一种危急的情况,可能导致急性呼吸困扰综合征.
传统中医药的京颗粒通过调节炎症,在减轻白血素诱导的ALI方面表现有前途.
在ALI中Jingfang颗粒的有效性背后的精确机制需要进一步阐明.

研究的目的:

评估Jingfang颗粒对抗白血素诱导的ALI的保护作用.
调查Jingfang颗粒在治疗ALI的基础药理机制.

主要方法:

通过腹腔内白血素注射建立一个ALI小鼠模型.
评估Jingfang颗粒对ALI和肺纤维化通过体重,肺外观,肺指数和组织病理学的影响.
使用网络药理学,蛋白质组学,代谢组学和西部斑分析来阐明机制.
整合网络药理学和分子对接,以确定治疗点.

主要成果:

京芳颗粒显著保护小鼠免受白胺诱导的ALI,其证据是体重改善,肺减少,肺组织病理和纤维化改善.
蛋白质组学,西部斑块学和代谢学发现,Jingfang颗粒通过降低PI3K/Akt/mTOR信号通路的调节来调节糖解/葡萄糖生成和Pyruvate代谢.
网络药理学和分子对接确定PI3K/Akt信号通路,包括MAPK1,MAPK3,JAK2,HRAS,EGFR,PIK3R1和PIK3CA等目标,对于Jingfang Granules在ALI中的作用至关重要.

结论:

京芳颗粒对白血素诱导的ALI具有显著的保护作用.
治疗作用涉及PI3K/Akt/mTOR信号通路的下调.
因此,这种调节调节了糖解/葡萄糖生成和酸盐代谢,突出了关键的作用机制.

关键词:

急性肺损伤是什么?急性肺损伤是什么?葡萄糖溶解是什么? 葡萄糖溶解京的颗粒是什么意思?在 PI3K/Akt/mTOR 信号通路中.肺部纤维化肺部纤维化

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