在急性胃肠炎患者中,Dientamoeba fragilis与微生物群多样性变化有关
M-R Muhsin-Sharafaldine1, L Abdel Rahman1, R Suwanarusk1
1Department of Microbiology & Immunology, University of Otago, Dunedin, New Zealand.
Parasitology international
|July 23, 2023
概括
这项研究发现了Dientamoeba fragilis和Blastocystis sp. 在胃肠炎中很常见. D. fragilis显著改变肠道细菌微生物群,这表明它在疾病发展中的作用.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 人类健康 人类健康 人类健康
背景情况:
- 胃肠炎是一种常见的疾病,具有复杂的病因.
- 肠道原生虫在胃肠炎中的作用尚未完全理解.
- 原生动物与细菌微生物群之间的相互作用是一个新兴的研究领域.
研究的目的:
- 研究肠道原生动物感染与胃肠炎患者细菌微生物群之间的相关性.
- 为了比较多重复合并联PCR的诊断效果与检测肠道寄生虫的传统方法.
- 确定流行的原生动物物种及其与微生物多样性的关联.
主要方法:
- 在新西兰,从463名被诊断患有胃肠炎的患者收集了便样本.
- 多复合串联PCR用于敏感检测肠道原生动物.
- 细菌微生物组的组成与原生动物的发现一起分析.
主要成果:
- 多复合串联PCR在检测寄生虫方面表现出比显微镜更高的灵敏度.
- 胚胎囊 sp. 的情况. 和Dientamoeba fragilis是最经常检测到的原生动物.
- 丁塔莫巴脆弱菌 (Dientamoeba fragilis) 与宿主 prokaryotic 微生物群的α-多样性增加有显著的积极关联.
结论:
- 在胃肠炎患者中,肠道原生虫,特别是Dientamoeba fragilis,与宿主 prokaryotic 微生物群有显著的相关性.
- D. fragilis对微生物多样性的影响表明,它可能在胃肠炎的发病过程中起作用.
- 需要进一步的研究来阐明这些原生动物对胃肠炎的确切贡献,并为疾病管理策略提供信息.
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