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对免疫检查点抑制剂的类反应

C Torrecilla-Vall-Llossera¹, A Jucglà Serra¹, J Molinero Caturla¹

¹Servicio de Dermatología, Hospital Universitari de Bellvitge, Hospitalet de Llobregat, Barcelona, España.

Actas dermo-sifiliograficas

|July 23, 2023

概括

免疫检查点抑制剂 (ICI) 可以引发免疫介导的皮肤反应,如状喷发. 这些反应通常是轻微的,通常不需要停止ICI治疗,并且需要组织学确认来区分与癌症进展.

科学领域:

皮肤病学皮肤病学
在瘤学瘤学.
免疫学免疫学免疫学

背景情况:

免疫检查点抑制剂 (ICI) 是革命性的癌症疗法.
已知的ICI副作用是免疫媒介的皮肤不良事件.
类反应是与ICI相关的皮肤不良事件之一.

研究的目的:

追溯分析皮肤上发生类反应的患者的临床和组织学数据.
了解ICI诱导的类反应的表现,诊断和管理.
为了区分ICI诱导的类反应与瘤进展.

主要方法:

临床和组织学数据的回顾性分析.
包括2019年至2022年期间接受ICI治疗的患者.
在所有情况下,组织学证实了类反应.

主要成果:

研究了7名患者 (6名女性,1名男性;中位数年龄65岁).
症状出现的中位时间为4个月.
常见的表现包括膝盖的乳头类沙尔科发症和皮下沙尔科发症.
组织学发现与异常性沙尔科毒症相似.
只有两名患者需要停止ICI治疗.
反应通常是轻微的,不需要停止治疗.

结论:

由ICI引起的样反应是一种独特的免疫媒介皮肤不良事件.
这些反应通常是轻微的,在不中断ICI治疗的情况下是可以控制的.
组织学检查对于准确诊断和排除瘤复发至关重要.

关键词:

这些都是颗粒体.免疫检查点抑制剂免疫检查点抑制剂免疫治疗是一种免疫疗法.免疫控制点抑制剂免疫控制点抑制剂免疫疗法是一种免疫疗法.Sarcoidosis 是一种癌症.

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