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酸盐信号减弱高脂肪饮食引起的代谢障碍和肠道屏障功能障碍

Xuan Li¹, Guowen Huang¹, Yanan Zhang¹

¹Laboratory of Gastrointestinal Microbiology, Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal Health, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China; National Center for International Research on Animal Gut Nutrition, Nanjing Agricultural University, Nanjing 210095, China.

Pharmacological research

|July 23, 2023

概括

苏酸盐-SUCNR1轴可以防止肥胖引起的肠道屏障损伤. 补充苏酸盐改善了小鼠的肠道健康,减少了小鼠的炎症,而阻断SUCNR1则加剧了这些影响.

科学领域:

代谢信号传递是代谢信号传递.
我们的肠道微生物群.
免疫学免疫学免疫学

背景情况:

酸盐是调节宿主代谢和炎症的关键代谢物.
在与肥胖相关的肠壁障碍功能障碍中,酸盐-SUCNR1轴的作用尚不清楚.

研究的目的:

调查酸盐-SUCNR1轴对高脂肪饮食引起的肠壁功能障碍的影响.

主要方法:

使用了 SUCNR1 缺乏的小鼠模型,食高脂肪饮食 (HFD).
评估肠道屏障功能,杯状细胞数量,粘液产生,炎症,肠道微生物群和透性.
通过食补充剂服用的苏酸盐.

主要成果:

HFD损害了肠道屏障功能,减少了杯状细胞和粘液,增加了炎症,失生症和透性.
饮食中的酸盐逆转了HFD诱导的肠道屏障缺陷,抑制了炎症,并改善了微生物群.
在HFD下,SUCNR1缺乏的小鼠没有显示肠道屏障功能或代谢健康的改善.

结论:

在肥胖期间,酸盐-SUCNR1轴在维持肠道屏障完整性方面发挥着至关重要的保护作用.
向苏酸盐-SUCNR1通路可能为与肥胖相关的肠道功能障碍提供治疗策略.

关键词:

炎症炎症是一种炎症.肠道屏障肠道屏障肠道屏障微生物群中的微生物群肥胖问题肥胖问题在 SUCNR1 中.苏酸盐是一种酸盐.

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