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在羊的生殖组织和大脑区域中,TRPM8的表达对表达生殖行为的重要

C M Sutton¹, R L Ziegler¹, K J Austin¹

¹Department of Animal Sciences, University of Wyoming, Laramie, WY 82071, United States.

Physiology & behavior

|July 23, 2023

概括

暂时受体潜在拉斯8 (TRPM8) 通道在男性生殖组织中更为丰富,但它在大脑中的存在似乎不会影响公羊的性行为.

科学领域:

生殖生物学生殖生物学
神经内分泌学神经内分泌学
离子通道研究

背景情况:

短暂受体潜在拉斯8 (TRPM8) 通道是一种温度敏感的离子通道.
TRPM8也被认为是受体,这表明它在生殖生理学中发挥了作用.
了解激素对TRPM8的调节对于生殖健康研究至关重要.

研究的目的:

调查激素环境对生殖相关的生殖腺组织和大脑区域TRPM8表达的影响.
为了确定TRPM8在大脑中的表达与公羊的性行为是否相关.

主要方法:

从母羊,公羊和割的雄羊 () 收集的组织.
量化TRPM8mRNA和蛋白质表达在淋巴细胞组织 (丸,卵巢,前列腺) 和大脑区域 (杏仁体,下丘脑,嗅觉球).
检查了TRPM8表达在雄羊的大脑与高与低的性活动.

主要成果:

在丸中,TRPM8的mRNA和蛋白质表达比在卵巢中更高.
前列腺TRPM8 mRNA在公羊中比其他动物更大.
杏仁体中的TRPM8表达在公羊中较高,但在下丘脑或嗅球中没有显著差异.
大脑中TRPM8的存在与公羊的性行为水平无关.

结论:

在完整的男性生殖组织中,TRPM8的表达更强大.
TRPM8通道存在于杏仁体和下丘脑中,但不在公羊的腹膜区域.
对于雄羊的性行为表达,TRPM8通道表达似乎并不至关重要.

关键词:

性行为性行为.在TRPM8中,我们可以使用TRPM8.测试激素测试激素是什么

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