冠状动脉微血管功能障碍和心肌梗塞与非阻塞性冠状动脉:我们站在哪里?
Abdul-Quddus Mohammed1, Fuad A Abdu1, Lu Liu1
1Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
European journal of internal medicine
|July 23, 2023
概括
心肌梗塞与非阻塞性冠状动脉 (MINOCA) 影响6-10%的心脏病发作患者,需要识别冠状动脉微血管功能障碍 (CMD) 等潜在原因,以更好地管理和预后.
科学领域:
- 心血管医学 心血管医学
- 临床心脏病学 临床心脏病学
- 翻译研究是翻译研究.
背景情况:
- 心肌梗塞与非阻塞性冠状动脉 (MINOCA) 在6-10%的心脏病发作患者中被诊断为心肌梗塞.
- 对于MINOCA患者来说,预后不佳,包括高死亡率和再住院率.
- 目前对MINOCA的临床管理是不确定的,这代表了大量未满足的需求.
研究的目的:
- 审查MINOCA的病理生理学理解.
- 讨论MINOCA和冠状动脉微血管功能障碍 (CMD) 的当前诊断技术.
- 概述MINOCA和CMD患者的管理策略.
主要方法:
- 关于MINOCA的当代科学和临床研究的审查.
- 对诊断方法进行分析,以确定MINOCA的潜在原因.
- 对评估冠状动脉功能的侵入性和非侵入性方法的评估.
主要成果:
- MINOCA可能源于各种原因,包括动脉样硬化,斑块破裂,血管和CMD.
- 冠状小血管功能障碍 (CMD) 是MINOCA的一个关键因素,影响缺血和预后.
- 基于冠状动脉功能评估的个性化管理改善了患者的治疗结果.
结论:
- 准确诊断潜在原因,特别是CMD,对于有效的MINOCA管理至关重要.
- 建议采用系统的诊断方法来确定特定的心脏病发作机制.
- 评估冠状动脉功能为MINOCA患者提供了显著的预后和治疗益处.
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