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PRKAA1预测预后,并且与胃癌的免疫特征有关
Yongyi Chen1,2, Siyu Chen1,2, Jing Zhu1,2
1Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, 310022, China.
Functional & integrative genomics
|July 23, 2023
概括
高表达PRKAA1,5-AMP激活蛋白激酶的α子单元,与晚期胃癌 (GC) 和低生存率有关. PRKAA1可能作为GC的预后生物标志物,与免疫细胞透相关.
科学领域:
- 生物化学 生物化学
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 5-AMP激活蛋白激酶 (AMPK) 在细胞能量恒温中起着至关重要的作用.
- AMPK的α子单元PRKAA1参与各种细胞过程,但其在胃癌 (GC) 中的作用尚不清楚.
研究的目的:
- 研究PRKAA1表达与临床参数,整体存活率,血液指数和胃癌患者的免疫透之间的关联.
主要方法:
- 使用ELISA,蛋白质图谱,UALCAN和GEPIA数据库分析了PRKAA1的表达.
- 使用TImer,DICE和蛋白质图谱数据库来评估免疫细胞透.
- 在高和低PRKAA1表达 (n=345) 的GC患者之间比较了临床特征,生存率和外周血液指数.
主要成果:
- 与健康个体相比,在GC患者的血清中,PRKAA1的调节显著上升.
- 较高的PRKAA1表达与远程转移,高级TNM阶段和UICC阶段IV相关.
- PRKAA1的表达与循环T细胞和免疫细胞透,特别是T细胞显著相关.
结论:
- 在胃癌中,PRKAA1的表达很高,与晚期疾病和整体生存率低下有关.
- PRKAA1可能作为胃癌的潜在预后生物标志物.
- PRKAA1的表达与胃癌中的免疫透物有关.
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