消化道癌不同病理亚型的MRI成像特征
Zhaoqi Wang1, Funing Chu1, Bingmei Bai1
1Department of Radiology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, No.127 Dongming Road, Zhengzhou, 450008, Henan, China.
European radiology
|July 23, 2023
概括
磁共振成像 (MRI) 显示了不同食道癌 (EC) 亚型的不同特征. 这些特定的MRI发现有助于预测瘤的阶段和等级,改善患者的预测结果.
科学领域:
- 放射学和医学成像学 医学成像学
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
背景情况:
- 食道癌 (EC) 包含各种病理亚型,具有潜在不同的临床行为.
- 准确的手术前评估EC亚型,T分期和分化对于治疗规划和预后至关重要.
研究的目的:
- 划分特定的磁共振成像 (MRI) 与食道癌不同病理亚型相关的特征.
- 评估这些MRI特征在预测瘤 (T) 阶段和病理差异化程度方面的有用性.
主要方法:
- 对201名食道癌患者进行MRI和食道切除术的前性研究.
- 两名放射科医生根据特定的MRI发现评估了病态特征 (局部,性,突出,透类型).
- 采用多逻辑回归模型来评估成像特征和EC亚型之间的关联.
主要成果:
- 在表征EC亚型时,获得了很高的读者间一致性 (ICC = 0.991).
- 具体的MRI发现包括局部型 (LT) 的完整的覆盖性粘膜,透型 (IT) 的"三明治"外观,以及型 (UT) 的线性/结节对立性粘膜.
- 突出的类型 (PT) 与T1阶段和等级1相关;IT与T3阶段和等级2-3相关. 大型LR模型显示出高预测性能 (AUC 0.870.97).
结论:
- 截然不同的食道癌病理亚型表现出特有的MRI外观.
- 这些MRI特征可以可靠地预测T阶段和病理差异化程度.
- 基于MRI的亚型可能会提供对治疗敏感性和患者存活率的见解.
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