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[对传染病应用的mNGS结果分析]

X W Jiang¹, Z K Liang¹, L Zeng¹

¹Research Center of Medical and Pharmaceutical Bioengineering, Ministry of Health, National and Regional Joint Engineering Laboratory for Clinical Medical Molecular Diagnostics, Guangzhou 510665, China.

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]

|July 24, 2023

概括

甲基因组下一代测序 (mNGS) 对传染病诊断有希望,但在识别关键病原体方面面临挑战,并且缺乏临床使用的统一解释标准.

科学领域:

微生物学微生物学
基因组学就是基因组学.
临床诊断临床诊断临床诊断

背景情况:

大基因组下一代测序 (mNGS) 正从研究转向临床环境.
技术进步和成本降低正在推动mNGS的采用.
mNGS在传染病预防,诊断,治疗和跟踪方面取得了成功.

研究的目的:

审查对各种系统的病原体感染mNGS结果的解释.
讨论mNGS数据的临床解释和应用规则.
为了突出mNGS解释准确的病原体诊断的挑战.

主要方法:

对传染病中的mNGS应用现有文献和案例报告的审查.
对解释mNGS结果的不同系统的分析.
对mNGS的临床指南和监管框架的审查.

主要成果:

mNGS可以在样本中检测到广泛的潜在病原体.
由于大量的微生物,准确识别致病原体仍然是一个重大挑战.
对临床mNGS数据缺乏标准化的解释标准.

结论:

尽管mNGS具有潜力,但其临床实施受到解释复杂性的阻碍.
标准化解释指南对于使用mNGS可靠的病原体诊断至关重要.
需要进行进一步的研究和达成共识,以克服目前mNGS解释方面的挑战.

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