核和图案之间的相互作用在剪切诱导结晶过程中从平行板几何平行板的溶液中产生结晶.
Cedric Devos1, Anja Vananroye1, Ruth Cardinaels1,2
1KU Leuven, Department of Chemical Engineering, Celestijnenlaan 200F, 3001 Leuven, Belgium. simon.kuhn@kuleuven.be.
Soft matter
|July 24, 2023
概括
在超和溶液中,剪切诱导的核化导致自发的晶体模式形成. 修改板表面可以控制这些结晶模式,对于药物净化至关重要.
科学领域:
- 化学工程是化学工程的重要组成部分.
- 材料科学 材料科学 材料科学
- 结晶科学 结晶科学
背景情况:
- 冷却结晶对于净化小型有机分子至关重要,特别是在药品中.
- 了解核和晶体生长是控制结晶过程的关键.
研究的目的:
- 为了研究小有机分子溶液中剪切诱导的核化.
- 了解在剪切下形成中等尺度圆形晶体图案的形成.
- 探索控制核和模式发展的机制.
主要方法:
- 使用平行板几何学研究在受控剪切条件下的结晶.
- 分析核化事件及其在板面上的空间分布.
- 研究剪切速率,时间和表面特性对结晶模式的影响.
主要成果:
- 核化优先发生在高剪速区域,特别是在板边.
- 观察到较短的核化时间与增加的平均切割速率和持续时间.
- 表面出现了圆形晶体图案,与异质核和拟议的棒滑运动机制有关.
结论:
- 一个涉及晶体棒滑动和二次核化的新奇机制解释了模式形成.
- 板表面的异质核在启动结晶模式中起着至关重要的作用.
- 表面修饰提供了一种控制结晶模式发展和净化结果的方法.
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