索福斯布维尔和达克拉塔斯维尔治疗慢性肝炎C病毒感染后的心血管风险评估
Kareem Ali Maher1, Reda Biomy1, Mahmoud Mohammed Youssef2
1Department of Cardiology, Kafrelsheikh University,Egypt.
JPMA. The Journal of the Pakistan Medical Association
|July 24, 2023
概括
索福斯布维尔和达克拉塔斯维尔联合治疗对于慢性型肝炎病毒患者是安全的,没有显著的心血管风险. 这种抗病毒治疗在研究队列中没有对心脏功能或主要心血管事件产生负面影响.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
背景情况:
- 慢性型肝炎病毒 (HCV) 感染对心血管疾病构成风险.
- 抗病毒疗法如索福斯布维尔和达克拉塔斯维尔用于治疗HCV.
- 在HCV治疗期间评估心血管安全是至关重要的.
研究的目的:
- 为了评估慢性型肝炎病毒患者的心血管风险,这些患者接受了sofosbuvir和daclatasvir治疗.
- 为了确定这种抗病毒联合治疗对心脏事件的安全性.
主要方法:
- 一项前性队列研究,涉及200名成年慢性型肝炎病毒患者,喷射分数>=40%.
- 根据心血管风险因素 (无,多,高血压,糖尿病,吸烟者) 将患者分组.
- 心血管事件和心声学参数在基线和经过12周治疗后进行评估.
主要成果:
- 在心痛,心律失常或呼吸障碍进展的发病率上没有发现显著变化 (p>0.05).
- 心声扫描显示平均射出分数,全球纵向应变和肺动脉压力 (p>0.05) 的非显著变化.
- 该研究包括一组不同心血管风险概况的不同患者.
结论:
- 索福斯布维尔和达克拉塔斯维尔联合治疗对于慢性型肝炎病毒患者是安全的.
- 治疗没有对心脏功能产生不良影响或增加心血管风险.
- 从心血管安全的角度来看,这一发现支持在HCV患者中使用这种治疗方案.
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