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介质素-6,介质素-10和介质素-2受体与重病COVID-19患者的死亡率之间的关系

Asmaa Embarak Hassan¹, Nahla Abdelaziz Nosair¹, Mohammed Hussien Ahmed²

¹Department of Clinical Pathology, Kafrelsheikh University,Egypt.

JPMA. The Journal of the Pakistan Medical Association

|July 24, 2023

概括

溶性互白素-2受体 (IL-2R),互白素-6 (IL-6) 和互白素-10 (IL-10) 的水平升高表明严重的COVID-19患者的死亡风险更高. 在幸存者中观察到这些细胞因子的较低水平,表明它们作为预后标记物的潜力.

科学领域:

免疫学免疫学免疫学
传染性疾病传染性疾病
关键护理医学关键护理医学

背景情况:

严重的COVID-19的特征是免疫反应失调.
介素-6 (IL-6),介素-10 (IL-10) 和可溶性介素-2受体 (IL-2R) 是关键的炎症类细胞因子,涉及严重感染.

研究的目的:

调查IL-2R,IL-6和IL-10血清水平与重症COVID-19住院患者的死亡率之间的联系.
探索这些细胞因子与炎症和凝血标记物的相关性.

主要方法:

一个单一中心的队列研究包括250名严重的COVID-19患者.
用化学发光免疫测试测量IL-2R,IL-6,IL-10,普卡尔西托尼和费里丁的血清水平.
使用SPSS版本25进行统计分析.

主要成果:

总共包括250名患者 (59%是男性,中位数年龄为57.5岁);40.8%的患者死亡.
与未幸存者相比,幸存者表现出显著较低的IL-2R,IL-6和IL-10水平 (p<0.001).
IL-2R,IL-6和IL-10水平与炎症标志物 (CRP,LDH,前素,费里丁) 和凝血参数 (D-二分体,纤维素原) 有正相关.

结论:

升高的IL-2R,IL-6和IL-10水平与严重的COVID-19中死亡风险增加有关.
这些细胞因子可以作为潜在的生物标志物,用于预测严重的COVID-19患者的结果.

关键词:

互乐金-6,互乐金-10,前素,纤维素片段D,COVID-19,发光,互乐金-2,免疫检测,纤维素,费里.

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