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Updated: Jun 19, 2026

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

碳纤维:对大鼠的炎症反应和毒性进行表征和评估

Clarissa Carvalho Martins Maciel¹, Letícia Cavassini Torquato¹, Eduardo Antonio Chelin Suárez¹

¹Department of Diagnosis and Surgery, Division of Periodontology, São Paulo State University (UNESP), Institute of Science and Technology, Sao Jose dos Campos, Brazil.

Journal of biomedical materials research. Part B, Applied biomaterials

|July 24, 2023

概括

非活性碳纤维料 (NACFF),活性碳纤维料 (ACFF) 和银活性碳纤维料 (Ag-ACFF) 显示出由于它们的水友性,吸收性和无毒性而具有合成骨移植支架的潜力.

科学领域:

生物材料科学生物材料科学
材料工程材料工程材料工程
组织工程是组织工程.

背景情况:

合成骨移植的开发对于骨缺陷的修复至关重要.
碳纤维材料由于其机械性能和可调的表面化学成分,具有作为支架的潜力.

研究的目的:

为了评估碳纤维材料 (NACFF,ACFF,Ag-ACFF,ACFT) 作为潜在的合成骨移植支架.
描述它们的物理,机械和生物特性,用于骨再生应用.

主要方法:

材料包括非活性碳纤维料 (NACFF),活性碳纤维料 (ACFF),银活性碳纤维料 (Ag-ACFF) 和活性碳纤维组织 (ACFT).
描述包括表面湿透性,引力和胀测试.
在体内评估包括对Wistar大鼠进行皮下植入,以评估炎症反应,原纤维形成和主要器官的全身毒性.

主要成果:

ACFF和Ag-ACFF表现出水友性,而NACFF和ACFT则是疏水的.
在ACFF中,ACFF表现出对最大应力具有优越的抵抗力.
在PBS溶液和蒸水中,ACFF和Ag-ACFF的吸收率最高.
在评估的器官中没有观察到急性全身毒性.
植入部位显示轻度至中度炎症;ACFT未能促进I型原体成熟.

结论:

NACFF,ACFF和Ag-ACFF显示出作为合成骨移植支架的巨大潜力.
这些材料具有有利的特性,包括良好的吸收性,水友性和生物相容性.
由于原纤维成熟不充分,ACFT对脚手架应用的潜力有限.

关键词:

生物相容的材料是生物相容的材料.骨再生骨再生碳纤维是一种碳纤维.脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架组织工程是组织工程.

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