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基于系统免疫炎症响应指数的诺莫格拉姆的开发和验证,用于预测ST升高心肌梗塞患者的对比诱导脏病
Faysal Şaylık1, Tufan Çınar2, Remzi Sarıkaya1
1Department of Cardiology, Van Education and Research Hospital, Van, Turkey.
Angiology
|July 24, 2023
概括
新的系统免疫炎症反应指数 (SIIRI) 能够有效地预测ST升高心肌梗塞 (STEMI) 患者的对比诱导脏病 (CIN),这些患者正在接受初级皮肤穿冠状动脉干预 (pPCI). 与系统性免疫炎症指数 (SII) 相比,SIIRI提供了更好的预测能力.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 炎症标志物的炎症标志物
背景情况:
- 对比诱导性脏病 (CIN) 是ST升高心肌梗塞 (STEMI) 的初级皮肤通冠状动脉干预 (pPCI) 后的一个显著并发症.
- 系统性免疫炎症反应指数 (SIIRI) 是一种新的炎症标志物,已经显示出与冠状动脉疾病严重程度的关联.
研究的目的:
- 评估SIIRI在PCI后的STEMI患者中对CIN发展的预测能力.
- 开发和验证一个使用SIIRI进行CIN风险分层的nomogram.
主要方法:
- 分析了接受pPCI的2289名STEMI患者的队列.
- 在pPCI后72小时内,CIN被定义为≥0.5 mg/dL或血清肌氨酸增加25%.
- 根据SIIRI和其他临床因素构建并验证了一个名图,用于预测基于SIIRI和其他临床因素的CIN风险.
主要成果:
- 患有CIN的患者 (219) 与没有 (2070) 患者相比,显示出显著更高的SIIRI水平.
- SIIRI被确定为CIN的独立预测因子,并且与系统性免疫炎症指数 (SII) 相比,它表现出优越的歧视.
- 基于SIIRI的名图显示出对预测CIN的良好校准和区别,在添加SIIRI时超过了基线模型.
结论:
- 在接受pPCI的STEMI患者中,SIIRI是一种有价值和独立的CIN预测器.
- 开发的基于SIIRI的nomogram为CIN的风险分层提供了一个有用的工具.
- 在这种患者群体中,SIIRI为CIN检测提供了比SII更好的预测性能.
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