卵泡淋巴瘤的个性化治疗 - 拨号是否正在转动?
Kim M Linton1,2, Lena Specht3,4, Astrid Pavlovsky5,6
1Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK.
Hematological oncology
|July 24, 2023
概括
毛囊淋巴瘤是一种常见的惰性非霍奇金淋巴瘤,其结果各不相同. 本综述涵盖了更新的风险分层和卵泡淋巴瘤的治疗方法,旨在提供个性化的护理.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 临床医学 临床医学
背景情况:
- 毛囊性淋巴瘤是最常见的惰性非霍奇金淋巴瘤,占西方国家新诊断的20%-25%.
- 虽然总体上是有利的,但结果各不相同,一些高风险群体的预后明显较差.
研究的目的:
- 审查最近风险分层和毛囊淋巴瘤治疗策略的进展.
- 讨论前期和复发/耐药性疾病的不断发展的治疗选择.
- 探索一个个性化的方法来管理毛囊淋巴瘤.
主要方法:
- 对风险分层的最新更新进行文献综述.
- 对毛囊淋巴瘤当前和新兴治疗方式的分析.
- 基于患者风险和疾病表型的个性化治疗策略的讨论.
主要成果:
- 在毛囊淋巴瘤的风险分层和治疗选择方面取得了重大进展.
- 该评论强调了针对复发性和耐火性卵泡淋巴瘤的越来越多的选择.
- 人们越来越多地考虑个性化治疗方法.
结论:
- 尽管取得了进展,但在基于个体患者风险的最佳治疗方案的前性选择方面仍然存在挑战.
- 预计对卵泡淋巴瘤生物学的进一步了解和诊断工具的改进将弥补这些差距.
- 个性化医疗有望改善卵泡淋巴瘤的结果.
更多相关视频
06:15Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma
Published on: October 27, 2014
27.4K
11:39Subcellular Fractionation of Primary Chronic Lymphocytic Leukemia Cells to Monitor Nuclear/Cytoplasmic Protein Trafficking
Published on: October 23, 2019
11.5K
相关概念视频
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
02:57Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
01:27Tumor Immunotherapy
560
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
560
02:56Treatment Resistant Cancers
3.3K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K