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通过血液动力学模拟分析横性肝脏内移植系统分流

Junjie Cao¹, Zhichao Yao¹, Guijun Huo¹

¹Department of Vascular Surgery, Gusu School of Nanjing Medical University, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital (HQ), Suzhou, China.

Bio-medical materials and engineering

|July 24, 2023

概括

穿过左门静脉 (LPV) 的8毫米分流直径为跨内肝移植系统分流 (TIPS) 程序提供了最好的结果. 这种方法优化了门静脉压力和肝脏血流,改善了门脉高血压的结果.

科学领域:

肝病学肝病学是一种肝病学.
干预性放射学干预性放射学
生物医学工程生物医学工程

背景情况:

跨内肝移植系统分流 (TIPS) 是门高血压 (PH) 的首要治疗方法.
目前的TIPS程序缺乏最佳的分流方案,以平衡并发症率和有效的静血.
开发改进的TIPS分流策略对于患者的治疗结果至关重要.

研究的目的:

构建肝硬化门口高血压的计算模型.
为了比较不同跨内肝移植系统分流 (TIPS) 分流方案的有效性.
为了确定一个最佳的TIPS变流策略,用于门高血压管理.

主要方法:

增强型计算机断层扫描 (CT) 扫描被用来创建肝硬化肝脏的3D模型.
模拟软件被用来设计各种跨内肝内移植系统 (TIPS) 冲刺配置.
计算流体动力学 (CFD) 模拟 (FLUENT) 分析了门静脉压力,肝 perfusion 和血流.

主要成果:

较宽的分流管直径与较低的门静脉压力和减少的肝血 perfusion.
一个6毫米的分流直径未能达到目标的压力下降.
通过左门静脉 (LPV) 穿过8毫米的分流直径显示出最高的性能系数 (G).

结论:

8毫米直径的分流器,特别是通过左门静脉 (LPV),显示了跨内肝移植系统分流 (TIPS) 程序的显著前景.
这种分流方案可能会导致更好的临床效果和更好的患者预后.
对这种优化的TIPS配置进行进一步调查是有必要的.

关键词:

跨内肝移植系统的分流.慢性肝脏疾病慢性肝脏疾病计算流体动力学流体动力学发生出血发生出血门口压力门户压力门户的压力.

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