根据唐氏综合征的智力障碍水平对阿尔茨海默氏病的时间表
Sigan L Hartley1,2, Victoria Fleming1,2, Emily K Schworer1
1Waisman Center, University of Wisconsin-Madison, Madison, WI, USA.
Journal of Alzheimer's disease : JAD
|July 24, 2023
概括
唐氏综合征 (DS) 的智力障碍水平 (ID) 不会改变与年龄相关的阿尔茨海默病 (AD) 生物标志物或认知能力下降的进展. 这一发现支持在AD临床试验中包括多样化的DS患者.
科学领域:
- 神经学 神经学
- 遗传学 遗传学 是一个
- 生物标志物 生物标志物
背景情况:
- 三胞胎症21号,是唐氏综合征 (DS) 的遗传原因,是早期阿尔茨海默病 (AD) 的已知危险因素.
- 了解影响AD进展的因素对于开发有效的干预措施至关重要.
研究的目的:
- 调查是否先发性智力障碍 (ID) 的水平会影响与年龄相关的AD生物标志物 (粉样β和PET) 的发展轨迹,以及DS的成年人的认知能力下降.
- 为了确定患有轻度,中度或严重/严重ID的个体是否随着时间的推移表现出AD生物标志物积累和认知障碍的不同模式.
主要方法:
- 利用了来自阿尔茨海默氏症生物标志物联盟-唐氏综合征 (ABC-DS) 队列的数据.
- 采用了一般线性混合模型来分析PET Aβ,tau PET的年龄轨迹,以及不同前病情ID水平的认知测量 (记忆,精神状态,视觉空间能力).
- 在分析中控制三症类型,APOE状态,生物学性别和研究地点.
主要成果:
- 根据年龄,预先患病的ID水平对认知结果没有显著的影响.
- 对于PET Aβ或tau PET生物标志物,没有发现因年龄而预先患病ID的显著影响.
- 对于患有轻度认知障碍-DS或痴呆症的个体,研究访问的年龄没有显著差异,这取决于他们患病前的ID水平.
结论:
- 这项研究提供了强有力的证据,表明阿尔茨海默病的发展轨迹在患有唐氏综合征的个体中,在不同程度的先发性智力障碍中以类似的方式展开.
- 这些发现支持在阿尔茨海默病的临床试验中更广泛地纳入患有唐氏综合征的个体,无论他们的智力障碍程度如何.
- 这项研究为阿尔茨海默病和唐氏综合征更具包容性和代表性的临床研究奠定了基础.
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