产后体重增加对非常早产婴儿大脑白质成熟的影响
Pratheek S Bobba1, Clara F Weber2, Adrian R Acuna Higaki1
1Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut, USA.
概括
在非常早产婴儿中,高出生体重和产后体重增加与更成熟的白质 (WM) 脑道有关. 这些发现强调了早期营养对早产婴儿神经发育的重要性.
科学领域:
- 新生儿神经科学 新生儿神经科学
- 神经成像是一种神经成像.
- 发育儿科 发育儿科
背景情况:
- 非常早产的婴儿 (<32周妊娠年龄) 经常经历神经缺陷.
- 连接出生体重和产后生长与VPI的神经结果的神经生物学机制尚未完全理解.
研究的目的:
- 调查出生体重和产后体重增加如何影响非常早产婴儿 (VPI) 白质成熟.
- 利用扩散张力成像 (DTI) 来描述这些关联.
主要方法:
- 包括91个VPI,包括完整的出生/产后体重数据和出院前的DTI扫描.
- 采用voxel-wise一般线性模型和基于通道的回归分析.
- 控制出生时的妊娠年龄和出生和扫描之间的时间.
主要成果:
- 较高的出生体重Z-分数与更成熟的WM通道相关,特别是在体和状条形体中.
- 增加的产后体重Z-score变化 (前4周) 也与增强的WM成熟度有关.
- 结果根据妊娠年龄,出生体重Z-score和扫描时间进行了调整.
结论:
- 在VPI中,出生体重和产后体重增加与可通过MRI检测的白质成熟标志物有关.
- 这些神经成像指标可以作为早期生物标志物,用于营养干预对VPI大脑发育的影响.
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