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Updated: Aug 17, 2026

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鱼类内分泌干扰剂综合测试 (iFEDT) 的开发-A部分:合并现有的鱼类测试指南

Pauline Pannetier1,2, Lisa Gölz1, Maria T Pissarreira Mendes Fagundes1

  • 1Aquatic Ecology and Toxicology Section, Centre for Organismal Studies, University of Heidelberg, Heidelberg, Germany.

Integrated environmental assessment and management
|July 24, 2023
PubMed
概括

科学家们开发了一种鱼体内分泌干扰剂综合测试 (iFEDT),以改善有害化学物质的检测. 这种新方法结合了现有的测试方法,并增加了甲状腺终点,用于全面的鱼类测试和环境安全评估.

关键词:
内分泌干扰物 干扰内分泌干扰物组织病理学 组织病理学经合组织测试指南斑马鱼是一种斑马鱼.

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...