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生物聚合物覆盖的皮拉津胺加载的胆固体体:在体外特征和生物可用性研究

Avi Singh¹, Sabya Sachi Das², Janne Ruokolainen³

¹Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi 835215, Jharkhand, India.

|July 24, 2023

概括

新的类体有效地提供了pyrazinamide (PZA),显著增加了血药物度. 这些带有PZA的颗粒显示出作为先进的药物载体的前景,用于有针对性的输送.

科学领域:

材料科学材料科学材料科学
制药科学制药科学
纳米技术纳米技术

背景情况:

皮拉津胺 (PZA) 是结核病治疗的关键药物.
开发有效的药物输送系统对于提高PZA生物可用性和疗效至关重要.
胆固醇体为封装和输送治疗剂提供了一个有前途的平台.

研究的目的:

为了准备和表征皮拉津胺 (PZA) 载荷的体体.
使用中央复合材料设计,优化PZA载荷合体的配方.
评估PZA载荷的类体的药物载荷,释放特征和药理动力学性能.

主要方法:

使用现场凝技术,用碳酸 (CaCO3) 贝制备了状体颗粒.
采用中央复合材料设计,以优化CaCO3,甲基酸盐和多3-xybutyrate-co-3-hydroxyvalerate (PHBV) 的度.
颗粒的特征包括场辐射扫描电子显微镜 (FESEM),FTIR,DSC,TGA-DTA和XRD分析.
进行了药理动力学研究,以比较PZA载荷的体体与PZA溶液.

主要成果:

最佳的配方产生了最大的药物负载和高效的释放特征.
FESEM证实了具有有效PHBV聚合物涂层的球形,多孔粒子.
光谱和热分析表明PZA和辅助剂之间的兼容性很好.
药理动力学研究表明,与PZA溶液相比,PZA装载的体体的血药物度 (AUC0-∞) 增加了4.26倍,Cmax更高.

结论:

准备的PZA载荷的体体显示出作为有效的药物载体的优秀潜力.
优化的配方确保了有效的药物加载和受控的释放.
体体技术提供了一种可行的策略,用于增强PZA输送和治疗结果.

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