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超吸收性聚合物颗粒的杀菌活性对于它们在呼吸道液体固化系统中的应用

Manju Saraswathy¹, Manoj Komath², Deepu Damodharan Ragini¹

¹Department of Biomaterial Science and Technology, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum 695012, India.

|July 24, 2023

概括

烯酸Sorb囊袋可以安全地固化和消毒传染性呼吸道分泌物. 浸消毒剂的超吸收聚合物 (DSAP) 颗粒,特别是DSAP-S5,具有有效的杀菌活性,并保持颗粒完整性,以确保医疗保健的安全.

科学领域:

防治和预防感染.
材料科学材料科学材料科学
微生物学微生物学

背景情况:

从传染性疾病中排出呼吸道分泌物的处理对医疗保健工作者构成感染风险.
烯酸Sorb装袋提供了一种通过固化和消毒来安全处理的解决方案.
这些袋使用了浸消毒剂的超吸收聚合物 (DSAP) 颗粒,其专利设计为增强吸收.

研究的目的:

评估DSAP颗粒对格拉姆阴性 (Klebsiella pneumoniae) 和格拉姆阳性 (MRSA) 细菌的杀菌效果.
为了评估DSP颗粒的固化能力.
为了确定AcryloSorb装袋的最佳消毒剂-SAP配方.

主要方法:

通过浸超吸收聚合物 (SAP) 与各种消毒剂,包括酸和二化酸盐,制备DSAP颗粒.
对克莱布西拉肺炎和耐美西林金黄色葡萄球菌 (MRSA) 的杀菌活性进行了测试.
评估了固化能力和消毒剂对SAP颗粒形态的影响.

主要成果:

用乙酸浸的SAP (DSAP-P) 显示100%的杀菌活性在0.5%的重量对两个细菌,但导致SAP颗粒崩.
与二化酸盐浸的SAP (DSAP-S5) 在5重量%时表现出100%的杀菌活性,并保留了SAP颗粒形态.
不同的消毒剂表现出不同的杀菌活性和对SAP结构的影响.

结论:

由于其有效的消毒,固化和保存SAP颗粒形态,DSAP-S5是AcryloSorb装袋的合适候选者.
该研究强调了平衡消毒剂有效性与材料稳定的重要性,以确保医疗废物安全管理.
烯酸吸收技术提供了一种有希望的方法,以减轻与处理传染性呼吸道分泌物相关的感染风险.

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