执行功能受损的高血压患者进行计算机化工作记忆训练:一项随机临床试验
Regina Silva Paradela1, Brenno Cabella2, Mariana Penteado Nucci3
1Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Frontiers in neuroscience
|July 24, 2023
概括
复杂工作记忆 (WM) 训练没有改善高血压患者的认知功能. 然而,它确实导致了关键区域的更高效的大脑活动,这表明了潜在的神经效益.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 临床医学 临床医学
背景情况:
- 高血压与工作记忆 (WM) 损害有关.
- 在高血压患者和执行功能 (EF) 缺陷的高血压患者中,Cogmed WM训练的有效性仍未得到研究.
- 这项研究解决了关于Cogmed对这一群体的影响的知识差距.
研究的目的:
- 评估Cogmed WM培训对EF损伤高血压患者认知表现的影响.
- 在Cogmed干预后使用功能磁共振成像 (fMRI) 探索神经元活动的变化.
主要方法:
- 40名高血压患者 (40-70岁) 随机获得了10周的Cogmed或对照训练.
- 认知结果,包括WM,口头记忆和执行功能,是初级和二级终点.
- fMRI用于测量低和高WM负载任务期间的大脑活动.
主要成果:
- 与对照组相比,Cogmed训练并没有显著改善WM或其他认知结果.
- 在Cogmed组中,fMRI显示右上额叶 (WM-低负荷) 和左下额叶 (WM-高负荷) 的激活减少.
- 这些激活变化表明,在训练后的WM相关网络中,神经处理更有效.
结论:
- 辅助WM训练没有提高EF损伤的高血压个体的认知表现.
- 尽管没有认知能力的改善,但观察到前双双脑大脑活动的减少表明,训练后神经元功能可能更有效.
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