瘤演变的芯片上建模:进展,挑战和机遇
Chengpan Li1,2, Joseph Benjamin Holman1, Zhengdi Shi1
1Department of Electronic Engineering and Information Science, University of Science and Technology of China, Hefei, Anhui, 230027, China.
Materials today. Bio
|July 24, 2023
概括
微流体瘤芯片模拟固体瘤及其微环境,为瘤进化和转移提供了洞察力. 这些平台通过可视化复杂的瘤细胞行为来推进癌症研究和治疗开发.
科学领域:
- 生物医学工程 生物医学工程
- 癌症生物学 癌症生物学
- 微流体学 微流体学
背景情况:
- 瘤进化,包括瘤发生到转移,受到瘤微环境 (TME) 的影响.
- 固体瘤进展的精确机制仍然不完全理解,限制了治疗进展.
- 微流体瘤芯片为模拟固体瘤和观察细胞行为提供了一种新的方法.
研究的目的:
- 审查在微流体芯片上设计固体瘤的方法.
- 总结最近使用微流体芯片研究瘤细胞行为方面的进展.
- 讨论瘤有机体与微流体平台的整合.
主要方法:
- 在微流体芯片上开发工程固体瘤.
- 考虑瘤类型,细胞来源,细胞外矩阵和TME组件.
- 对微流体芯片应用的审查,以观察瘤细胞的增殖,迁移和免疫逃逸.
主要成果:
- 微流体芯片可以可视化瘤细胞的行为,如增殖,上皮细胞转移到介质细胞,迁移,输血,输血和免疫逃生.
- 与瘤有机体的集成可以创建先进的瘤有机体在芯片上的平台.
- 确定了当前瘤芯片技术的实际局限性.
结论:
- 微流体瘤芯片是模拟固体瘤和了解瘤进展的强大工具.
- 这些平台有助于在受控的微环境中研究复杂的瘤细胞动态.
- 需要进一步开发以克服增强治疗应用的现有局限性.
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