横向肌痛炎在髓寡腺细胞糖蛋白抗体相关的疾病中
Gina Perez-Giraldo1, Natalia Gonzalez Caldito1, Elena Grebenciucova1
1Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Frontiers in neurology
|July 24, 2023
概括
横侧髓炎 (TM) 是髓寡细胞抗体相关疾病 (MOGAD) 的常见症状. 由于MOG抗体水平和成像结果的波动,诊断可能具有挑战性,影响治疗决策.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 神经免疫学 神经免疫学
背景情况:
- 横侧髓炎 (TM) 是二次最常见的髓寡干细胞抗体相关疾病 (MOGAD) 的表现,约有26%的患者见过.
- 诊断挑战包括非特异性MOG抗体标位,波动的血清阳性,以及正常或已解决的MRI发现的可能性.
研究的目的:
- 审查MOGAD相关TM的诊断特征.
- 讨论MOGAD相关TM的放射性特征和管理策略.
- 突出复发的风险和临床试验的需要.
主要方法:
- 对MOGAD相关TM的临床,放射和脑脊液 (CSF) 发现的审查.
- 对MOG抗体标位和血清阳性变化的分析,以用于诊断.
- 评估有关TM呈现,复发风险和治疗的现有文献.
主要成果:
- 由于可变的MOG抗体水平和成像,MOGAD相关的TM诊断是复杂的.
- 关于疾病进展的不确定性 (单相与复发) 和缺乏FDA批准的治疗方法限制了治疗选择.
- 呈现时的TM可能表明未来复发的风险更高.
结论:
- 准确诊断MOGAD相关TM需要仔细考虑临床,血清学和放射学数据.
- 进一步的随机临床试验对于建立有效的治疗算法至关重要.
- 了解复发风险对于指导长期管理策略至关重要.
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