抗中性细胞质抗体相关血管炎的急性冠状动脉综合征:韩国单中心队列研究
Jin Seok Kim1, Yong-Beom Park1,2, Sang-Won Lee1,2
1Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
Journal of rheumatic diseases
|July 24, 2023
概括
患有抗中性子细胞质抗体 (ANCA) 相关血管炎 (AAV) 的患者中急性冠状动脉综合征 (ACS) 的发生率为2.7%. 非ST段升高心肌梗塞 (NSTEMI) 是最常见的ACS类型,男性性别是预测因素.
科学领域:
- 心脏病学 心脏病学
- 类风湿病学 类风湿病学
- 内部医学 内部医学
背景情况:
- 反中性细胞质抗体 (ANCA) 相关的血管炎 (AAV) 是一组系统性自身免疫性疾病.
- 患有AAV的患者患有心血管事件的风险增加.
- 了解AAV中心血管风险概况对于患者管理至关重要.
研究的目的:
- 为了确定急性冠状动脉综合征 (ACS) 的发生率和模式,在患有AAV的患者中.
- 在被诊断患有AAV的韩国患者队列中确定ACS的预测因子.
主要方法:
- 一个单一中心的队列研究包括262名被诊断患有AAV的患者.
- 急性冠状动脉综合征 (ACS) 被定义为在AAV诊断期间或之后发生的ST段升高心肌梗塞 (STEMI),非STEMI (NSTEMI) 或不稳定性胸痛 (UA).
- 分析了临床变量,以确定ACS的预测因素.
主要成果:
- 在AAV患者中,ACS的发病率为2.7% (7名患者).
- 非ST段升高心肌梗塞 (NSTEMI) 是最常见的ACS类型.
- 男性性别被确定为AAV患者中ACS的唯一显著预测因素.
结论:
- 在韩国患有AAV的患者中,ACS的发病率为2.7%.
- 在这个人群中,NSTEMI是ACS的主要形式.
- 男性的性别是AAV患者中ACS发展的重要风险因素.
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