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Updated: Jul 22, 2025

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在非小细胞肺癌中使用血样本检测KRAS突变:系统性审查和元分析

Peiling Cai¹, Bofan Yang², Jiahui Zhao²

¹Department of Anatomy and Histology, School of Preclinical Medicine, Chengdu University, Chengdu, China.

Frontiers in oncology

|July 24, 2023

概括

血KRAS突变检测显示了对非小细胞肺癌 (NSCLC) 诊断的良好准确性. 这种液体活检方法是一个可行的替代方案,当瘤组织是不可用的.

科学领域:

在瘤学瘤学.
分子诊断学分子诊断学
基因组学就是基因组学.

背景情况:

非小细胞肺癌 (NSCLC) 的诊断通常依赖于瘤组织分析.
KRAS突变是NSCLC的关键驱动因素,影响治疗决策.
需要使用非侵入性诊断方法来改善患者的可访问性和减少手术风险.

结论:

基于等离子体的KRAS突变检测在NSCLC患者中提供了良好的诊断准确性.
使用血样本进行液体活检可以作为瘤组织的有效替代品.
这种方法提高了诊断能力,特别是当组织活检是不可行的.

关键词:

克拉斯 (Kras) 是一个国家.诊断的准确性诊断的准确性这是一个元分析.非小细胞肺癌的肺癌.血等离子体是什么?

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相关概念视频

The Ras Gene

The Ras Gene

The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a...