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复发性缓解性和渐进性多发性硬化症患者的疼痛和参与社会活动

Dhruv Jain¹, Charles N Bernstein², Lesley A Graff³

¹Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.

Multiple sclerosis journal - experimental, translational and clinical

|July 24, 2023

概括

疼痛在多发性硬化症亚型中几乎是普遍存在的,影响超过95%. 虽然进展性多发性硬化症患者经历了更多的疼痛干扰和较少的社会参与,但亚型并没有最终预测这些差异.

科学领域:

神经学神经学
疼痛管理疼痛管理
多发性硬化症研究研究

背景情况:

疼痛是多发性硬化症 (MS) 中常见但尚未研究的症状.
了解MS亚型之间的疼痛差异对于有针对性的治疗至关重要.

研究的目的:

为了比较疼痛的患病率及其与疼痛干扰的关联以及在复发性复发性多发性硬化 (RRMS) 和渐进性多发性硬化 (PMS) 中的社会参与.

主要方法:

使用麦吉尔疼痛问卷,疼痛效应量表和参与社会角色和活动的能力问卷.
采用定量回归来分析MS亚型,疼痛严重程度和功能结果之间的关联.

主要成果:

在RRMS和PMS中,疼痛 (95.2%) 和与疼痛相关的限制 (87%) 的高患病率,没有显著的亚型差异.
与RRMS患者相比,进展性MS患者报告疼痛干扰更大,社交参与减少.
多变量分析,控制共变量,表明MS亚型与疼痛干扰或社会参与之间没有显著的关联.

结论:

疼痛是患有多发性硬化症的个体几乎普遍的体验,不管是什么亚型.
虽然初步分析表明RRMS和PMS之间疼痛干扰和社会参与的差异,但考虑到其他因素后,这些并没有独立地与MS亚型相关.

关键词:

多发性硬化症是多发性硬化症.疼痛干扰疼痛干扰疼痛的严重程度疼痛的严重程度参与参与参与参与社会活动社交活动

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