相关实验视频

Updated: Jul 22, 2025

How to Measure Cortical Folding from MR Images: a Step-by-Step Tutorial to Compute Local Gyrification Index

How to Measure Cortical Folding from MR Images: a Step-by-Step Tutorial to Compute Local Gyrification Index

Published on: January 2, 2012

在轻度认知障碍中,β-粉样蛋白和皮质厚度之间的纵向关联

Elijah Mak¹, Liwen Zhang^2,3, Chin Hong Tan^4,5

¹Department of Psychiatry, University of Cambridge, Cambridge, CB2 2QQ, United Kingdom.

Brain communications

|July 24, 2023

概括

在特定的大脑区域中粉样蛋白的积累与轻度认知障碍中的大脑缩和记忆衰退相关. 在健康对照组中没有观察到这种关系,这表明粉样蛋白.

科学领域:

神经科学是一个神经科学.
神经学神经学
阿尔茨海默氏症疾病研究研究

背景情况:

在阿尔茨海默病 (AD) 中,beta-amyloid积累和大脑缩之间的关系是有争议的.
关于粉样蛋白如何影响神经退行,存在相互矛盾的发现.

研究的目的:

研究轻度认知障碍 (MCI) 和没有认知障碍 (NCI) 的个体中区域大脑缩和粉样蛋白沉积之间的相关性.
测试一种假设,即较大的皮层稀释与MCI中的粉样蛋白沉积相关,特别是在易患AD的区域.

主要方法:

45名MCI患者和12名NCI对照患者接受了[11C]-匹兹堡化合物B PET用于粉样蛋白成像.
纵向结构成像 (23.65±2.04个月的随访) 评估了区域皮层厚度.
线性混合模型分析了全球/区域粉样蛋白和纵向皮层稀释之间的关系.

主要成果:

在MCI中,上角的右边区域性粉样蛋白与右侧中间轨道前皮层的纵向皮层稀释相关 (p=0.04).
较大的粉样蛋白负担和右中间轨道前皮层皮层的皮层厚度降低与MCI的记忆力下降有关.
在这两组中,全球粉样蛋白水平与纵向皮层稀释没有相关性.

结论:

粉样蛋白对神经退行和记忆力的影响在临床前到前期阿尔茨海默氏症的疾病谱中增加.
需要进一步的多模式研究来澄清各种病理与粉样蛋白和记忆衰退的相互作用.

关键词:

[11C]-PiB PET 的使用情况.皮层厚度皮层厚度纵向皮层稀释纵向皮层稀释轻度的认知障碍轻度的认知障碍地区性β-氨酸.

更多相关视频

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Published on: December 18, 2016

Longitudinal In Vivo Imaging of the Cerebrovasculature: Relevance to CNS Diseases

Longitudinal In Vivo Imaging of the Cerebrovasculature: Relevance to CNS Diseases

Published on: December 6, 2016

相关概念视频

Alzheimer's Disease: Overview

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...

Association Areas of the Cortex

Association Areas of the Cortex

Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...