最近被诊断出患有年轻缓解性双相I型障碍和风险人群的神经认知缺陷:潜在的内分类型?
Preethi V Reddy1, Nandhini Bojappen1, Rajkumari P Reddy2
1Dept. of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India.
Indian journal of psychological medicine
|July 24, 2023
概括
认知缺陷在双相情感障碍 (BD) 的早期显而易见. 患有BD高风险的年轻亲属表现出语言流性和视觉记忆障碍,这表明早期诊断和干预的潜力.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 遗传学 遗传学 是一个
背景情况:
- 神经认知缺陷在优性双极性障碍 (BD) 中始终被观察到.
- 关于认知缺陷作为印度次大陆BD的内类型的有限数据存在,特别是在20-25岁的年龄组.
- 这项研究调查了最近被诊断患有BD的年轻人,他们的未受影响的一级亲属和健康对照的认知缺陷.
研究的目的:
- 检查神经认知缺陷作为双极性障碍 (BD) 的潜在内分类型.
- 评估最近被诊断出第一次发作躁狂 (FEM) 的缓解期患者,年轻高风险 (HR) 亲属和健康对照 (HC) 的认知功能.
- 为了研究BD发病的关键年龄范围 (20-25岁) 内的个体的认知表现.
主要方法:
- 横截面研究涉及25名FEM患者,25名HR亲属和25名年龄相匹配的HC患者.
- 参与者年龄在18-30岁之间;人力资源组所有人年龄在25岁以下.
- 使用NIMHANS神经心理学电池进行神经认知评估,涵盖处理速度,注意力,记忆和执行功能.
主要成果:
- 在多个认知领域,FEM患者的表现低于HC患者.
- 在口语流 (COWA) 和视觉记忆 (CFT-IR) 方面,HR个体表现比HC更差.
- 在某些领域,HR患者的认知表现与FEM患者的认知表现相当.
结论:
- 认知障碍在双相情感障碍的很早阶段就存在.
- 视觉记忆和口头流性缺陷显示出作为BD的内类型的潜力.
- 研究结果强调了早期诊断和预防性干预在BD的可能性,特别是在脆弱年龄段的高风险个体中.
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