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在瘤免疫疗法中准LSD1:理由,挑战和潜在的潜力

Lei Bao^1,2, Ping Zhu^3,4, Yuan Mou^1,2

¹Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang, China.

Frontiers in immunology

|July 24, 2023

概括

氨酸特异性去甲基酶1 (LSD1) 抑制可以增强抗瘤免疫力,并改善患者对免疫疗法的反应,如免疫检查点抑制剂 (ICI). 这一策略有望通过调节瘤微环境来治疗各种癌症.

科学领域:

生物化学生化学
免疫学免疫学免疫学
在瘤学瘤学.

背景情况:

氨酸特异性去甲基酶1 (LSD1) 对于癌症的发展和进展至关重要.
在瘤微环境 (TME) 中,LSD1影响瘤细胞和免疫细胞.
目前的免疫疗法,如免疫检查点抑制剂 (ICI),由于瘤诱导的免疫抑制,在许多患者中显示出有限的疗效.

研究的目的:

审查了解LSD1在瘤免疫力中的作用的最新进展.
探索将LSD1抑制与癌症治疗的免疫疗法结合在一起的潜力.

主要方法:

关于LSD1,瘤免疫和免疫治疗的最新研究的文献综述.
分析LSD1影响瘤微环境和免疫反应的机制.
讨论LSD1抑制与ICI结合的临床前和临床证据.

主要成果:

抑制LSD1可以将瘤微环境从"冷"重新编程为"热",增加免疫细胞透.
LSD1阻塞增强了瘤细胞对免疫检查点抑制剂 (抗PD-L) 和CAR-T细胞治疗的敏感性.
在TME中,LSD1在调节瘤细胞适应和免疫细胞功能方面发挥着重要作用.

结论:

抑制LSD1是一种有前途的策略,可以克服对当前免疫疗法的耐药性.
将LSD1抑制剂与ICI结合起来,可能为癌症治疗提供一种更有效的方法.
对LSD1向疗法的进一步研究是有必要的,以改善瘤学患者的治疗结果.

关键词:

一个LSD1一个LSD1 在PD-(L) 1 组合疗法治疗组合治疗.免疫疗法免疫疗法瘤微环境是一个微环境.

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