舌头涂层微生物组组成反映了中国南京COVID-19患者的疾病严重程度
Zongdan Jiang1, Lu Yang2, Xuetian Qian1
1Department of Gastroenterology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Journal of oral microbiology
|July 24, 2023
概括
在COVID-19患者中,舌膜微生物组显著不同,细菌组成的变化与疾病严重程度相关. 这一发现可能有助于早期识别COVID-19患者的病情.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 基因组学就是基因组学.
背景情况:
- 口腔微生物组在健康和疾病中起着重要作用.
- 了解COVID-19患者的微生物变化对于疾病管理至关重要.
研究的目的:
- 调查舌头涂层微生物群与COVID-19严重程度之间的关联.
- 为了探索COVID-19患者状况的潜在早期生物标志物.
主要方法:
- 16S rRNA基因测序来自130名参与者的口腔抽样 (37名健康人,49名轻度/中度COVID-19,44名重度/危急COVID-19).
- 对α和β多样性的分析.
- 对于分类学差异的线性差异分析效应大小 (LEfSe).
主要成果:
- 与健康对照组相比,在轻度/中度和重度/危急的COVID-19组中,舌头涂层微生物丰富度显著更高.
- 鉴定出不同的微生物特征,包括在COVID-19患者中降低了Prevotella,Neisseria,Fusobacterium,Alloprevotella,增加了Streptococcus,Rothia.
- 特定的细菌,如 Pseudomonas, Acinetobacter, Lactobacillus, Corynebacterium 和 Rothia 在严重/危急病例中更为丰富.
结论:
- 在COVID-19患者中,舌头涂层微生物组的组成发生了改变.
- 舌头涂层中的微生物特征可能与COVID-19的严重程度相关.
- 这些发现表明早期检测和评估COVID-19患者状况的潜力.
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