在COVID-19后,在唾液和血中检测到持续的免疫和凝血功能障碍
Hyesun Jang1, Saibyasachi Choudhury2, Yanbao Yu3
1Genomic Medicine and Infectious Diseases, J. Craig Venter Institute, La Jolla, CA, and Rockville, MD, USA.
Heliyon
|July 24, 2023
概括
这项研究揭示了COVID-19康复过程中持续的炎症和免疫细胞功能障碍,突出了唾液作为监测长期健康和炎症后果的关键液体.
科学领域:
- 免疫学 免疫学 免疫学
- 蛋白质组学是指蛋白质组学.
- 传染性疾病 传染性疾病
背景情况:
- COVID-19 (冠状病毒疾病2019) 与正在进行的炎症问题有关.
- 从COVID-19中恢复正常与病态恢复的分子细节仍然不清楚.
研究的目的:
- 在COVID-19康复期间表征免疫和蛋白质组反应.
- 为了探索唾液作为监测液体的实用性.
主要方法:
- 来自COVID-19患者的匹配血和唾液样本的分析,症状解决后20-90天.
- 全球免疫概况和猎枪蛋白质组学.
- 与疾病严重程度和抗体水平的相关性分析.
主要成果:
- 康复期患者表现出强烈的IgA和IgG抗体反应.
- 蛋白质组学发现了持续的炎症,包括中性粒细胞功能障碍和血凝固因子改变.
- 唾液显示IgA度较高,并改变了与SARS-CoV-2 IgA相关的髓状细胞路径.
结论:
- 持续的炎症和凝血异常发生在COVID-19后.
- 唾液是一种有前途的非侵入性液体,用于监测COVID-19后的免疫反应和后果.
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