乌尔旺/银纳米粒子水凝薄膜用于烧伤伤口
Evi Sulastri1,2, Ronny Lesmana3, Muhammad Sulaiman Zubair2
1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, 45363, Indonesia.
Heliyon
|July 24, 2023
概括
一种新的乌尔旺-银纳米粒子水凝膜敷料有效治疗二度烧伤. 这种先进的伤口带通过减少炎症和改善组织再生来加速愈合.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 纳米技术纳米技术
背景情况:
- 乌尔万是一种绿藻多糖,表现出有前途的水凝膜包装特性.
- 银纳米粒子 (AgNP) 增强抗菌活性和治疗烧伤的潜力.
研究的目的:
- 开发和评估一种新的水凝薄膜伤口包裹,其中包括乌尔万和银纳米粒子.
- 评估开发的敷料的物理化学性质,抗菌活性和体内伤口愈合疗效.
主要方法:
- 使用两种银酸盐度 (0.5mM和1mM) 制备了Ulvan-银纳米粒子水凝膜 (UHF-AgNP).
- 物理化学表征包括粒子大小,泽塔潜力,FTIR,XRD和SEM-EDX.
- 评估了Wistar大鼠体外抗菌活性和体内二度烧伤伤口愈合.
主要成果:
- 与UHF-AgNP1和对照组 (UHF膜) 相比,UHF-AgNP0.5配方表现出更高的抗菌活性.
- 在体内研究表明,UHF-AgNP0.5显著加快了二度烧伤愈合.
- 加速愈合是由于调节的炎症,增强的再上皮化和改善的血管化.
结论:
- 乌尔万-银纳米粒子水凝膜有效地加速二度烧伤的愈合.
- 这些新的水凝膜显示出作为先进的伤口带的巨大潜力,用于治疗烧伤.
相关概念视频
Phases of Wound Repair
6.1K
Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
6.1K
Burn Injuries
2.6K
Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
2.6K


